Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 54 5 2025 05 01 1054 1063 Kumayl Abbas Meghji Department of Physiology, Isra University, Hyderabad, Pakistan Tariq Feroz Memon Department of Community Medicine and Public Health Sciences, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan Abdul Raqeeb Department of Internal Medicine, Hafar Al-Batin Central Hospital, Ministry of Health, Hafar Al Batin, Saudi Arabia Muhammad Fahad Pathan Department of Family Medicine, Islington House Medical Centre, Liverpool, United Kingdom Usaid Raqeeb Department of Emergency, Ascension Bay Medical Care Hospital, Panama City, Florida, United States Tariq Zafar Shaikh Department of Internal Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan 2024 07 07 2024 11 25 Background: Chronic liver disease (CLD) and its end-stage manifestation, cirrhosis, present significant global health challenges, contributing to substantial morbidity and mortality. Despite its impact on various organ systems, the musculoskeletal effects of CLD, particularly vitamin D deficiency remain underexplored. This study aimed to identify significant predictors of vitamin D deficiency among CLD patients. Methods: Overall, 177 CLD patients of either gender, aged 18 yr and above were included using the non-probability consecutive sampling technique. This cross-sectional study was conducted at the medical units of Isra University Hospital, Hyderabad, from Jan to Jun 2023. Various markers of hepatic function including bilirubin, albumin, and International normalised ratio (INR), were analyzed, along with a complete blood count and each patient was assigned a Child-Turcotte-Pugh (CTP) score. The relationship of vitamin D with different variables was assessed through Chi-Square tests. Pearson correlation and regression analyses were carried out to identify predictors of vitamin D deficiency. Results: Mean age of patients was 51.76±5.77 yr and the majority were male (68.4%). Vitamin D deficiency was present in 28.24%, particularly among those with cirrhosis. Vitamin D levels correlated negatively with disease severity, as indicated by CTP (P<0.05) and Model for End-Stage Liver Disease (MELD) (P<0.05) scores, and positively with albumin levels (P<0.05). Increasing age, male gender, and higher CTP and MELD scores were significant predictors (P<0.05) of vitamin D deficiency. Conclusion: Vitamin D levels correlate with hepatic dysfunction and are negatively associated with disease progression. Significant predictors of vitamin D deficiency identified include increasing age, male gender, and higher MELD and CTP Score. https://ijph.tums.ac.ir/index.php/ijph/article/view/36003 https://ijph.tums.ac.ir/index.php/ijph/article/download/36003/8552