Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 44 4 2015 04 15 512 21 Ali Akbari Sari Dept. of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Ali Kazemi Karyani Dept. of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Seyed Moayed Alavian Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran. Mohamad Arab Dept. of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Fateme Rostami Gholmohamadi Vice Chancellery of Treatment, Qazvin University of Medical Sciences, Qazvin, Iran. Satar Rezaei Dept. of Public Health, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. 2015 10 14 Background: According to importance of cirrhosis of the liver and the lack of information about the economic burden of the disease, we performed this study to estimate the economic burden of liver Cirrhosis in Iran in 2011. Methods: The cost-of-illness method, based on the human capital theory, has been used. Both direct and indirect costs have been estimated using a prevalence approach and bottom-up method. The inpatient and outpatient records were investigated for obtaining the medical costs. Also, a questionnaire was used for collection the other data such as transportation costs, out of pocket payment and times of inpatients, etc. Costs consisted of expenditures which happened during March 2011 to February 2012 and the perspective of the study was Iranian society. Results: The total cost of the disease was 2014.5 billion Rials (USD164.32 million). Direct and indirect costs were 1384.16 and 630.4 billion Rials (86.7% and 11.3% of the total cost), respectively. Cost due to premature death was USD 38.66 million, included 23.52% of the total cost and 75% of indirect cost. Conclusion: Liver Cirrhosis impose enormous economic burden on Iranian society. Policymakers should therefore take this into consideration and according to available health resources provide services and facilities for the prevention and treatment of the disease https://ijph.tums.ac.ir/index.php/ijph/article/view/3594 https://ijph.tums.ac.ir/index.php/ijph/article/download/3594/3269