Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 6 2024 06 11 1322 1331 Milena Zlatanovic 1. Department of Medical Studies, The Academy of Applied Preschool Teaching and Health Studies Krusevac, Cuprija, Serbia 2. Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Ardea Milidrag Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Marija Sorak Department of Gynecology and Obstetrics, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Sanja Kocic Department of Social Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Aleksandar Visnjic Department of Social Medicine and Public Health, Faculty of Medicine, University of Niš, Niš, Serbia Mile Despotovic Department of Medical Studies, The Academy of Applied Preschool Teaching and Health Studies Krusevac, Cuprija, Serbia Teodora Safiye Department of Psychology, State University of Novi Pazar, Novi Pazar, Serbia Milena Despotovic Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Christos Alexopoulos Department of Medical Studies, The Academy of Applied Preschool Teaching and Health Studies Krusevac, Cuprija, Serbia Svetlana Radevic Department of Social Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia 2024 04 08 2024 06 11 Background: This study aimed to examine the quality of life and the factors that determine the quality of life of infertile couples. Methods: The research was conducted as a cross-sectional study at the Gynecology and Obstetrics Clinic "Narodni Front" in Belgrade, the Special Gynecology Hospital "Ferona" in Novi Sad, the Special Hospital for the Treatment of Sterility and In Vitro Fertilization "Spebo Medikal" in Leskovac and the General Hospital in Valjevo, Serbia in 2022, on a sample of 378 infertile couples. The data were collected by means of a questionnaire, the integral part of which is the standardized FertiQoL scale. Independent t-test and one-way ANOVA were used to determine differences. A value of P<0.05 was considered statistically significant. Results: Women achieve a significantly lower score on the quality of life questionnaire (69.34±11.05) compared to men (73.96±9.87). Women exhibit significantly lower scores in the area of physical, emotional and social functioning (P<0.05). Men who live in the countryside show a lower quality of life score in the emotional (P=0.029) and social (P=0.042) domains. In addition, men over 40 years of age and with a high level of education have a lower quality of life (P=0.08). Conclusion: Women have a lower quality of life, as do men from rural areas and over 40 years of age. A multidisciplinary approach and community education, as well as the provision of social support with a special emphasis on emotional and material support, would significantly contribute to improving the quality of life of infertile couples. https://ijph.tums.ac.ir/index.php/ijph/article/view/35110 https://ijph.tums.ac.ir/index.php/ijph/article/download/35110/8264