Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 54 2 2025 02 08 414 423 EN Mirjana Nedovic Vukovic 1. Center for Health System Evidence and Research in Public Health, Institute of Public Health of Montenegro, Podgorica, Montenegro 2. Faculty of Medicine, University of Montenegro, Podgorica, Montenegro Zoran Terzic 1. Faculty of Medicine, University of Montenegro, Podgorica, Montenegro 2. Center for Plastic and Reconstructive Surgery, Clinical Center of Montenegro, Podgorica, Montenegro Mileta Golubovic 1. Faculty of Medicine, University of Montenegro, Podgorica, Montenegro 2. Center of Pathology, Clinical Center of Montenegro, Podgorica, Montenegro Milos Bojic 1. Faculty of Medicine, University of Montenegro, Podgorica, Montenegro 2. Center for Plastic and Reconstructive Surgery, Clinical Center of Montenegro, Podgorica, Montenegro Marko Vukovic 1. Faculty of Medicine, University of Montenegro, Podgorica, Montenegro 2. Department of Urology, Clinical Center of Montenegro, Podgorica, Montenegro 2024 02 21 2024 09 01 Background: Bladder cancer accounts for more than 200,000 deaths annually on a global level, with an age-standardized mortality rate of 2.9 per 100,000 individuals. Despite declining global rates, it remains a substantial public health burden. We aimed to analyze the mortality trend of bladder cancer in Montenegro and identify the measures taken to combat this tumor. Methods: Bladder cancer mortality data in Montenegro from 1990 to 2021 were collected. Mortality rates were age-standardized to the World Standard Population. The joinpoint, linear and Poisson regressions were used to assess bladder cancer mortality trend. Results: There was a consistent increase in mortality rates due to bladder cancer, with statistical significance for both the overall population and specifically for males, with an average annual percent change (AAPC) of 1.5% (95% CI: 1.5 (0.5-2.9)) and 1.6% (AAPC (95% CI): 1.6 (0.4-3.3)) respectively. Additionally, there was a notable annual increase in the number of bladder cancer cases: average annual increase was 3.4% for the overall population, 3.5% in male and 2.9% in female, with statistical parameters (AAPC (95% CI), P-value) for join point regression: 3.4 (2.4-4.8), <0.001; 3.5 (2.3-5.1), 0.003; and 2.9 (1.2-5.1), 0.004, respectively. The majority of bladder cancer deaths occurred in the age groups of 65-74 (35.8%), 75-84 (33.6%), and 55-64 (16.8%). Conclusion: The ongoing increase in bladder cancer mortality in Montenegro, particularly among men and elderly should encourage policymakers to take action to reverse this unfavorable trend. https://ijph.tums.ac.ir/index.php/ijph/article/view/34697 https://ijph.tums.ac.ir/index.php/ijph/article/download/34697/8477