Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 7 2024 07 07 1560 1568 Yeting Chang Department of Cardiology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116000, China Qin Yu Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116000, China 2023 09 04 2024 07 07 Background: To investigate the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on blood pressure, blood glucose and blood lipid in diabetic patients with hypertension. Methods: A total of 300 diabetic patients and essential hypertension admitted to our hospital from January 2021 to December 2022 were selected, and divided into an observation group and a control group using a random number table method. The control group was treated with conventional antihypertensive drugs, hypoglycemic drugs, and lipid-lowering drugs. The observation group was supplemented with liraglutide on the basis of the control group. Blood pressure, blood glucose and blood lipid of the two groups were compared at the initial stage of medication and after 4 weeks and half a year, and the influencing factors of patients with persistent hypertension were further analyzed through Logistic regression. Results: After 4 weeks and 6 months of medication, inter group comparisons showed that systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG) and glycated hemoglobin (HbA1c), as well as total cholesterol (TC), triacylglycerol (TG), and plasma arteriosclerosis index (AIP) in the observation group were significantly lower than those in the control group (Ρ <0.05). Multivariate Logistic regression model analysis showed that age, smoking history, drinking history, taking conventional antihypertensive drugs, taking hypoglycemic drugs, taking lipid-lowering drugs, BMI, FBG, HbA1c and LDL-C were independent influencing factors for persistent hypertension (Ρ<0.05). Conclusion: GLP-1RAs can effectively improve the indexes including blood pressure, blood glucose and blood lipid in diabetic patients with hypertension. https://ijph.tums.ac.ir/index.php/ijph/article/view/33123 https://ijph.tums.ac.ir/index.php/ijph/article/download/33123/8288