Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 6 2024 06 11 1343 1351 Yang Li Department of Medical Examination, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Chi-na Yu Wang Ward 2, Department of Neurology, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China Teng Zhao Department of Intensive Care Medicine, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Chi-na Xuewen Yang Department of Nursing, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China Yinghui Lv Department of Geriatrics, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China Shumei Li The General Practice Ward, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China Xiujun Yang Honorable Community, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China Li Li Department of Nursing, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China 2023 08 30 2024 06 11 Background: We aimed to explore the effect of multi-sensory stimulation on apathy symptoms in elderly patients with Alzheimer's disease (AD). Methods: Eighty elderly patients with AD admitted to the Third Affiliated Hospital of Qiqihar Medical University, China from January 2022 to February 2023 were selected as the research objects by convenient sampling method. According to the random number table, they were divided into intervention group and control group, with 40 cases in each group. The control group was given routine nursing, while the intervention group was given multi-sensory stimulation based on this nursing. Apathy evaluation scale (AES), Behavioral pathology in Alzheimer’s disease rating scale (BEHAVE-AD) and Quality of Life Scale for dementia patients（QoL-AD） were used to compare the results. Results: Compared with the control group, the scores of AES and BEHAVE-AD in intervention group were lower (t was -7.312 and 11.88 respectively, P < 0.05), and the scores of QoL-AD in intervention group were significantly higher than those in control group were (t was -15.311, P < 0.01). Conclusion: Multi-sensory stimulation can relieve apathy symptoms, mental and behavioral symptoms and improve the quality of life of elderly patients with AD, which is worth popularizing in clinical practice. https://ijph.tums.ac.ir/index.php/ijph/article/view/33075 https://ijph.tums.ac.ir/index.php/ijph/article/download/33075/8266