Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 5 2024 05 04 1033 1046 Abdolkazem Neisi 1. Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 2. Environmental Health Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Fatemeh Koshki Nasab Environmental Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Arefeh Sepahvand Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran Bita Falahi Department of Nursing, Aligoudarz School of Nursing, Lorestan University of Medical Science, Khorramabad, Iran Masoume Taherian Department of Environmental Health Engineering, School of Public Health, Ahvaz Jundishapur University of Medical Sci-ences, Ahvaz, Iran Ali Farhadi Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran Parisa Asban Department of Environmental Health Engineering, School of Public Health, Ahvaz Jundishapur University of Medical Sci-ences, Ahvaz, Iran Nastaran Taleb Pour Environmental Health Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Majid Farhadi Environmental Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Abdullah Darghahi 1. Department of Environmental Health, Khalkhal University of Medical Sciences, Khalkhal, Iran 2. Social Determinants of Health Research Center, Ardabil University of Medical Sciences, Ardabil, Iran 2023 05 19 2023 10 04 Background: We aimed to verify the exposure to mercury in the air and its effect on cardiovascular disorders. Methods: The review was conducted using PubMed, Scopus, Web of Science, Embase, and national databases (such as SID) from 1995-2022. Results: Mercury exposure can cause many disorders in humans, including neurodevelopmental disorders in fetuses and children, adverse cardiovascular outcomes, hypertension, and diabetes. Mercury is a human neurotoxin, and in recent years its potentially harmful effects on cardiovascular disease (CVD) have raised concerns, mainly due to mercury's role in reducing oxidative stress. Conclusion: Possible mechanisms of mercury toxicity in CVD include mercury-selenium interaction, increased lipid peroxidation, and oxidative stress. In this article, we review studies that have investigated the relationship between mercury and CVD. https://ijph.tums.ac.ir/index.php/ijph/article/view/32090 https://ijph.tums.ac.ir/index.php/ijph/article/download/32090/8242