Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 38 3 2009 09 15 24 30 MR Abbaszadegan Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad Univers H Asadzadeh Aghdayi Internal Medicine Ward, Razavi Hospital, Mashhad, Iran F Rastin Dept. of Obstetrics & Gynecology, Imam Reza Hospital, MUMS, Mashhad, Iran E Dadkhah Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad Univers M Lotfalizadeh N Mohamadian Roshan M Farzadnia A Velayati A A'rabi 2015 10 03 Background: This study was designed to determine the frequency of Microsatellite Instability (MSI) in young Iranian pa­tients with endometrial carcinoma and to evaluate its association with histopathologic and clinical features of disease. Methods: Microsatellite status was analyzed in 23 patients with endometrioid type endometrial cancer who were less than 55 years. Clinicopathologic characteristics such as age, International Federation of Gynecology and Obstetric (FIGO) grad­ing and staging of tumor, family history of Hereditary Non-polyposis Colorectal Cancer (HNPCC), oral conception (OC) consump­tion, number of pregnancies, fertility, menstrual cycles and underlying disease were considered. Chi-square and Fisher exact tests were used to find the significant relationships. Results: MSI analysis showed 8 patients (34.8%) were MSS (Microsatellite Stable), 15 patients (62.5%) were MSI positive. Among cases with MSI phenotype, 4 cases (17.4%) had low instability (MSI-L) and 11 cases (47.8%) had high instability (MSI-H). Three cases with MSI-H had family history of HNPCC related cancers. Five cases (21.7%) had infertility in which 4 of them (80%) had MSI phenotype. There was no statistically significant relationship between MSI phenotype and tumor grade and stage. Conclusion: Few studies reported high frequency of MSI among young patients. Some studies mentioned similar results in endo­metrioid type of tumor. This study showed even higher frequency (65%) when MSI analyzed in young endometrioid type endometrial patients. Most cases with infertility had MSI-H phenotype. It may suggest that beside women with family his­tory of HNPCC, EC screening using MSI would be beneficial in infertile women too.   https://ijph.tums.ac.ir/index.php/ijph/article/view/3167 https://ijph.tums.ac.ir/index.php/ijph/article/download/3167/2966