Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 39 4 2010 12 15 70 77 M Moshki H Ashtarian 2015 10 03 Background: Health locus of control (HLC) has been associated with a variety of ailments and health outcomes and de­signed to predict behaviors and cognitive processes relevant to mental and physical health. This study investigated the relation­ships between perceived health locus of control, self-esteem, and mental health status among Iranian students. Methods: In this analytical study the subjects were recruited from students in Gonabad University of Medical Sci­ences, Iran, who studied in the first year (N=154). Students completed the questionnaires for assessing demographic, per­ceived health locus of control, self - esteem and psychological well- being data. Results: The statistical analysis revealed a negative relationship between perceived Internal HLC and self-esteem with psychologi­cal well-being. The positive correlation of the perceived Chance HLC with psychological well-being was statisti­cally significant (r= 0.21, P< 0.01) and the positive correlation of the perceived Internal HLC with self-esteem was statisti­cally significant (r= 0.25, P< 0.01). A significantly direct relationship between low perceived Internal HLC, self-esteem and psychological problems was found among these students. Conclusion: The findings will be addressed in relation to their implications for effective mental health education based on health locus of control especially internal and powerful others beliefs associated with self-esteem for students. This will re­quire additional monitoring and uninterrupted trying in order to be effective. https://ijph.tums.ac.ir/index.php/ijph/article/view/3083 https://ijph.tums.ac.ir/index.php/ijph/article/download/3083/2882