Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 8 2023 08 06 1656 1664 EN Li-Hua Qian 1. Clinical Medical College of Yangzhou University, No. 136 Middle Jiangyang Road, Hanjiang District, Yangzhou 225000, China 2. Department of Obstetrics and Gynecology, Taixing People's Hospital, No. 1 Changzheng Road, Taixing City, Taizhou 225400, China Xiang Kong 3. Department of Obstetrics and Gynecology, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China 4. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, China 5. Jiangsu Key Laboratory of Experimental & Translational Noncoding RNA Research, Yangzhou, Jiangsu, China Liu-Lin Zhou Department of Obstetrics and Gynecology, Taixing People's Hospital, No. 1 Changzheng Road, Taixing City, Taizhou 225400, China 2022 12 15 2023 04 07 Background: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease, usually occurring in the third trimester of pregnancy. Its typical clinical manifestations are itching and elevated serum total bile acid levels, which are more harmful to the fetus, and can lead to a variety of adverse pregnancy outcomes. This paper discusses the expressions of galectin -1 and 3 in the serum and placenta of ICP patients and their relationship with the effect of the incidence of ICP. Methods: Galectin-1 and 3 in serum and placenta were detected in 22 pregnant women with ICP and 20 healthy pregnant women admitted to the obstetrics Department of Northern Jiangsu People's Hospital from May 2021 to February 2022. Results: Serum levels of galectin-1 and galectin-3 in ICP pregnant women were significantly higher than those in controls, with significant differences (P<0.05). Placental galectin-1 and 3 were higher in normal pregnant women, and there were statistical differences between groups (P<0.05). Conclusion: In ICP, the maternal serum and placental galectin-1 and 3 levels were significantly increased, both of which may play an important role in the development of ICP, which may be the initiation factor of ICP pathophysiology, a marker of ICP prediction, and a target of ICP prevention strategies. https://ijph.tums.ac.ir/index.php/ijph/article/view/30683 https://ijph.tums.ac.ir/index.php/ijph/article/download/30683/8008