Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 2 2024 01 30 414 424 Maja Milosevic Markovic Department of Public Health, School of Dental Medicine, University of Belgrade, Belgrade, Serbia Milan Petrovic Clinic for Maxillofacial Surgery, School of Dental Medicine, University of Belgrade, Belgrade, Serbia Milan Latas Clinic for Psychiatry, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia Igor Djordjevic Clinic for Prosthodontics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia Srdjan Milovanovic Clinic for Psychiatry, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia Svetlana Jovanovic Department of Public Health, School of Dental Medicine, University of Belgrade, Belgrade, Serbia 2022 08 03 2023 04 07 Background: Oral squamous cell carcinoma (OSCC) has numerous physical, psychosocial and financial implications, which significantly affect patients' quality of life. We aimed to determine the health-related quality of life (HRQoL) and identify quality of life (QoL) predictors in patients with OSCC. Methods: We included 64 consecutive patients aged 40 to 80 yr treated for OSCC from Jan to Dec 2021. Health-related QoL was evaluated using the 30-item Cancer Quality of Life Questionnaire (QLQ-C30) and the 35-item Head and Neck Cancer-Quality of Life Questionnaire (QLQ-H&N35). The demographic questionnaire and clinical parameters were also presented. Results: The functioning scale in the QLQ-C30 questionnaire with the lowest average score was Global health status. The mean QLQ-C30 summary score (80.92 ± 10.4) was higher than the Global health status score (50.5 ± 22.2). In the QLQ-H&N35 questionnaire, the symptoms with highest scores were weight loss, dry mouth, and social eating. Linear regression analysis demonstrated that Global health status score was associated with education level [β-coefficient = 19.33 (95% CI: 10.7-24.9, P=0.004], alcohol consumption [β-coefficient=10.04 (95% CI: 4.5-14.8), P=0.023] and invasive surgical procedure [β-coefficient=22.75 (95% CI: 15.0-30.5), P=0.002]. The QLQ-C30 summary score was associated with living alone [β-coefficient= -20.05 (95% CI: −29.91-(−10.21), P=0.018], smoking status [β-coefficient=4.35 (95% CI: 1.8-6.91), P=0.043] and alcohol consumption [β-coefficient =4.59 (95% CI: 1.99-7.19), P=0.037]. Conclusion: We found several significant predictors of worse perception of HRQoL among patients with OSCC, which may be useful for specific prevention and treatment in order to achieve better QoL.   https://ijph.tums.ac.ir/index.php/ijph/article/view/29466 https://ijph.tums.ac.ir/index.php/ijph/article/download/29466/8167