Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 37 Supple 2 2008 12 15 7 15 H Saghafi Endocrinology and Metabolism Research Center of Tehran University of Medical Sciences, Iran A Hossein-nezhad Endocrinology and Metabolism Research Center of Tehran University of Medical Sciences, Iran N Sedighi Radiology Department of Shariati Hospital, Tehran University of Medical Sciences, Iran P Tofighi Endocrinology and Metabolism Research Center of Tehran University of Medical Sciences, Iran A Soltani Endocrinology and Metabolism Research Center of Tehran University of Medical Sciences, Iran B Larijani Endocrinology and Metabolism Research Center of Tehran University of Medical Sciences, Iran R Hafezi Physical Medicine & Rehabilitation, Baghiatallah University of Medical Sciences, Tehran, Iran 2015 10 03 Background: The aim of this study was to investigate the relationship among circulating levels of OPG, RANKL, cytokine profiles, bone mineral density (BMD) and vertebral fractures in pre and postmenopausal women and comparing these find­ing in three groups including osteoporotic patients with and without fracture and healthy women. Methods: In a cross-sectional study, 215 women who attended the BMD unit of Endocrinology & Metabolism Research Center (EMRC) of Tehran University of medical sciences were recruited. Serum Osteoporotegerin and sRANKL were measured. In addition, cytokines profile evaluated. Lumbar radiographs in the antero-posterior and left lateral projections were acquired following a standardized protocol and bone mineral densitometry was performed. Results: In X-ray study, 65.2% of postmenopausal women and 34.8% of pre menopausal women had at least one vertebral fracture (P= 0.04). Serum OPG and TNFα concentration significantly correlated with age (OPG: P= 0.001, r= 0.22, TNFα: P=0.04, r= 0.15). In logistic regression model, RANKL/OPG ratio independent of age and BMD was predicted vertebral fractures. Conclusion: Osteoimmunological insight in to vertebral fracture indicated that important role of proinflammatory cytokines and RANKL/OPG pathway in bone remodeling. https://ijph.tums.ac.ir/index.php/ijph/article/view/2892