Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 51 9 2022 09 04 2041 2047 Mo Li Department of Breast Surgery, Cancer Hospital of China Medical University, Shenyang 110042, Liaoning Province, China Xianxin Xie Department of Breast Surgery, Cancer Hospital of China Medical University, Shenyang 110042, Liaoning Province, China Hui Xu Department of Breast Surgery, Cancer Hospital of China Medical University, Shenyang 110042, Liaoning Province, China Hui Li Department of Breast Surgery, Cancer Hospital of China Medical University, Shenyang 110042, Liaoning Province, China 2022 04 01 2022 06 29 Background: We aimed to evaluate the effect of a psychological nursing intervention on inflammatory factors, negative emotions and quality of life in patients with breast cancer. Methods: Patients at the Cancer Hospital of China Medical University from January 2017 to January 2020 were stratified into two groups based on the way of nursing. Patients in the control group received routine care, and the experimental group received appropriate psychological care interventions in addition to routine care. We compared the inflammatory factors (interleukin-6 (IL-6) and C reactive protein (CRP)), negative emotions (self-rating depression scale (SDS) and self-rating anxiety scale (SAS)) and quality of Life (short form-36 survey (SF-36)) between two groups. Results: A total of 226 patients with breast cancer were enrolled in this study. Before the intervention, the CRP, IL-6, SAS and SDS between two groups were not significantly different (t=0.205, 0.971, 0.590, 1.579; P=0.838, 0.332, 0.556, 0.116). After the intervention, the CRP, IL-6, SAS and SDS between two groups were decreased and significantly different (t=-17.648, -18.079,-18.267,-18.613; P<0.05)  Besides, the social function , physiological function, mental health, physical pain, physical limitation, vitality, emotional functions and overall health were improved and  significantly different between two groups after intervention (P<0.05). Conclusion: A psychological nursing Intervention has the beneficial effect on the inflammatory factors, negative emotions and quality of life in patients with breast cancer. https://ijph.tums.ac.ir/index.php/ijph/article/view/28291 https://ijph.tums.ac.ir/index.php/ijph/article/download/28291/7717