Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 51 8 2022 08 11 1817 1826 Qiang Li The First Affiliated Hospital of Xingtai Medical College, Xingtai, Hebei Province, China Yibing Liu Department of Medical Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China Zhe Meng The First Affiliated Hospital of Xingtai Medical College, Xingtai, Hebei Province, China Qingfeng Ge The First Affiliated Hospital of Xingtai Medical College, Xingtai, Hebei Province, China Liyan Zhao The First Affiliated Hospital of Xingtai Medical College, Xingtai, Hebei Province, China Huiying Chu The First Affiliated Hospital of Xingtai Medical College, Xingtai, Hebei Province, China Xiaomin Li The First Affiliated Hospital of Xingtai Medical College, Xingtai, Hebei Province, China Jingli Chen Hebei Medical University, Shijiazhuang, Hebei Province, China Qingju Meng The First Affiliated Hospital of Xingtai Medical College, Xingtai, Hebei Province, China 2022 01 26 2022 06 29 Background: We aimed to analyze the predictive role of serum test and questionnaire in Early Gastric Cancer in The First Affiliated Hospital of Xingtai Medical College, Hebei Province from 2019 to 2020. Methods: In this prospective study, 280 medical examiners underwent questionnaire, serum test and gastroscopy. They were divided into Gastric cancer (GC) and Non-Gastric cancer (NGC) group. NGC group was divided into Low-grade intraepithelial neoplasia (LGIN), Chronic atrophic gastritis (CAG) and Non-chronic atrophic gastritis (NCAG) group. Results: Age, drinking, sex and Gastrin-17(G-17) was respectively independent risk factors for GC. Age, drinking and G-17 was independent risk factors for GC in men. G-17 of GC group was higher than that of LGIN and NCAG group (P<0.05). Pepsinogen I/II ratio (PGR) of GC was lower than that of NCAG group (P<0.05). There was no significant difference between Pepsinogen I (PGⅠ) and Pepsinogen II (PGII) in the four groups. Helicobacter pylori-immunoglobulin G antibodies (H. pylori-IgG) of LGIN group was significantly higher than that of CAG and NCAG group in gastritis group (P<0.008). G-17≥42.95 pmol/L, age≥69years, male and drinking can predict GC. Conclusion: Older, drinking, men and high G-17 could respectively predict GC. Especially in men, older, drinking and high G-17 could affect the occurrence of GC. G-17, age, drinking and sex used respectively to screen high-risk populations for GC were more efficient than combined screening. GC had a higher serum G-17 and a lower PG than other gastric diseases. https://ijph.tums.ac.ir/index.php/ijph/article/view/27643 https://ijph.tums.ac.ir/index.php/ijph/article/download/27643/7688