Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 41 1 2012 01 15 59 65 K Ghatreh Samani Dept. of Biochemistry, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, I M Noori Drug Applied Research Center and Biotechnology Research Canter, Tabriz University of Medical Scienc M Rohbani Nobar Drug Applied Research Center and Biotechnology Research Canter, Tabriz University of Medical Scienc M Hashemzadeh Chaleshtory Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran E Farrokhi Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran M Darabi Amin Drug Applied Research Center and Biotechnology Research Canter, Tabriz University of Medical Scienc 2015 10 03 Background: The T allele of the hepatic lipase (HL) C-514T polymorphism was previously found to be associated with lower plasma HL activity. Here, we examined the association between this polymorphism and plasma HDL-cholesterol concentrations in patients with coronary arteries stenosis. Methods: We studied 342 subjects undergoing coronary angiography in two groups of non CAD (n=146) and CAD (n=196). -514C→T polymorphism was determined using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results: After adjustment  for age, smoking  and body mass index, HDL-cholesterol concentrations were significantly higher  in men with the C/T&T/T genotype than those with the C/C genotype(mean 38.6 and 34.7 respectively P=0.01). The frequency of T allele in non CAD was 0.136 and 0.226 in female and male respectively and 0.170 and 0.223 for female and male in CAD subjects. There was no difference in T allele frequency in CAD and none CAD groups in male and female (P=0.466 and 0.722 respectively). Conclusion: -514C→T of LIPC gene have a positive effect on HDL-C concentration especially in male gender. However, no difference was determined in frequency of T allele between CAD and normal arteries subjects. https://ijph.tums.ac.ir/index.php/ijph/article/view/2634 https://ijph.tums.ac.ir/index.php/ijph/article/download/2634/2614