Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 3 2023 03 02 453 462 EN Saniya Saussakova Department of Public Health and Management, NJSC “Astana Medical University”, Astana, Kazakhstan Gaukhar Dauletova RSE on PCV "Research and production center of Transfusiology" of the Ministry of health and social development of the Republic of Kazakhstan Zhandulla Nakipov Department of Public Health and Management, NJSC “Astana Medical University”, Astana, Kazakhstan Gulzat Sarsenbayeva Department of Medical Insurance and Public Health, South Kazakhstan Medical Academy, Shymkent, Kazakhstan Samal Duisekova Department of Public Health and Management, NJSC “Astana Medical University”, Astana, Kazakhstan Zhanat Sadibekova Department of Social Health Insurance and Public Health, South Kazakhstan Medical Academy, Shymkent, Kazakhstan Karlygash Raissova Department of Public Health and Management, NJSC “Astana Medical University”, Astana, Kazakhstan Assiya Turgambayeva Department of Public Health and Management, NJSC “Astana Medical University”, Astana, Kazakhstan 2021 08 30 2022 12 21 Background: Chronic hepatitis B virus (CHB) infection is one of the most common liver infections worldwide. Approximately 240 million patients are diagnosed with CHB. The objective of this meta-analysis was to identify the effect of CHB on the affected patients’ health-related quality of life and compare with the control group. Methods: A comprehensive search was conducted through PubMed, Medline, ProQuest, Cochrane Central Register of Controlled Trials, Clinicaltrials.gov, and Web of Science databases up to Jul 2022. Results: Five primary observational studies using SF-36 and WHOQOL surveys with 1135 participants (646 with CHB and 489 healthy individuals) included in the meta-analysis. We evaluated the scores of physical and mental component summaries. HRQoL was comparable in both groups. The disease's impact appears to slightly affect the mental component summary than the physical component summary. Conclusion: The HRQoL in CHB patients is mainly reflected in the impairment of the mental aspect. It is vital to focus on optimally managing care, family and social support, stress management. https://ijph.tums.ac.ir/index.php/ijph/article/view/26118 https://ijph.tums.ac.ir/index.php/ijph/article/download/26118/7873