Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 51 10 2022 10 05 2308 2316 Nurbek Igissinov 1. Department of Surgical Diseases, Astana Medical University, Nur-Sultan, Kazakhstan 2. Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan 3. Eurasian Institute for Cancer Research, Bishkek, Kyrgyzstan Asem Toguzbayeva 1. Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan 2. Center of mammology, Kazakh Research Institute of Oncology and Radiology, Almaty, Kazakhstan Zhansaya Telmanova 1. Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan 2. Department of General Medical Practice, Astana Medical University, Nur-Sultan, Kazakhstan Aida Baibusunova 1. Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan 2. Department of General Medicine, Astana Medical University, Nur-Sultan, Kazakhstan Almazhan Abdykalikova Department of Oncology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan Gulnur Igissinova 1. Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan 2. Department of Oncology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan Zarina Bilyalova Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan Olzhas Akyshev 1. Department of Surgical Diseases, Astana Medical University, Nur-Sultan, Kazakhstan 2. Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan Serikbay Orazbayev 1. Department of Surgical Diseases, Astana Medical University, Nur-Sultan, Kazakhstan 2. Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan Zhanar Kozhakhmetova 1. Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan Department Zhanerke Azhetova 1. Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan 2. Department of Obstetrics and Gynecology, Astana Medical University, Nur-Sultan, Kazakhstan Gaukhar Nurtazinova 1. Department of Surgical Diseases, Astana Medical University, Nur-Sultan, Kazakhstan 2. Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan Yerlan Kuandykov 1. Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan 2. Department of General Medical Practice, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan, Kazakhstan 2021 08 21 2022 01 16 Background: The study conducted a component analysis of the dynamics of the incidence of breast cancer (BC) in Karaganda region. Methods: Primary data were for registered patients with BC (ICD 10–C50) in Kazakhstan, Karaganda region the period of 2009-2018. Evaluation of changes in BC incidence in the population of Karaganda was performed using component analysis according to the methodological recommendations. Results: Overall, 4,391 new cases of BC and 1,202 deaths were recorded. The incidence rate increased from 44.4 (2009) to 72.7 in 2018 and the overall growth was 28.37 per 100,000 population of female, including due to the age structure – ∑ΔA=3.13, due to the risk of acquiring illness – ∑ΔR=22.69 and their combined effect – ∑ΔRA=2.56. The component analysis revealed that the increase in the number of patients with BC was mainly due to the growth of the population (ΔP=+3.7%), changes in its age structure (ΔA=+10.3%) and changes associated with the risk of acquiring illness (ΔR=+75.0%). The mortality rate in the region changed from 18.6 (2009) to 10.9 (2018) and tended to decrease. Conclusion: The role of the influence of demographic factors and the risk of acquiring illness on the formation of the number of patients and the incidence of BC was evaluated. In this region, these indicators were the highest. The implementation of the results of this study is recommended in management of anticancer activities for BC. https://ijph.tums.ac.ir/index.php/ijph/article/view/26026 https://ijph.tums.ac.ir/index.php/ijph/article/download/26026/7749