Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 41 11 2012 11 15 92 97 A Tahmasebpour N Baradaran Rafiee S Ghaffari A Jamal 2015 10 03 Background: To study the outcome of cases with nuchal translucency (NT) ≥ 95th centile in the first trimester of pregnancy. Methods: This cross sectional study was performed at Iranian Fetal Medicine Foundation (FMF) between January 2009 and December 2011. Totally, 186 cases with NT≥ 95th centile who attended for the first trimester screening were studied. All cases with increased NT including those with normal karyotype were followed up with anomaly scan at 18-22 weeks and fetal echocardiography at 22-24 weeks. Pregnancy outcome was extracted from delivery records and pediatrics notes and telephone interviews. Results: Of screened cases, 186 fetuses had an NT≥95th centile, of them 19.8% were abnormal karyotype, including 29 cases of trisomy 21, three of trisomy 18, two of trisomy 13, three of Turner syndrome. 77.8% did not show any abnormalities on follow-up examinations. 4.6% of cases were found to have malformation antenatally and 4% cases postnatally. 11.4% women elected termination of pregnancy without further follow up. There were 4.6% fetal loss and  1.3% hydrops fetalis. Conclusion: In this unselected population, the study showed one out of four fetuses with enlarged NT had an adverse pregnancy outcome (miscarriage, fetal loss, and fetal abnormalities), however the chance of having a normal child after exclusion of chromosomal abnormalities and adverse pregnancy outcome was 95%. https://ijph.tums.ac.ir/index.php/ijph/article/view/2492 https://ijph.tums.ac.ir/index.php/ijph/article/download/2492/2472