Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 51 6 2022 06 08 1210 1222 Sedigheh Rastegar Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ghazaleh Heydarirad Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Zeinab Aryanian Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Dermatology, Babol University of Medical Sciences, Babol, Iran Maryam Shekofteh Department of Medical Library and Information Science, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Azam Shahbodaghi Department of Medical Library and Information Science, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Shirin Fahimi 5. Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Azadeh Goodarzi Department of Dermatology, Rasoul Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran Sanaz Poshtmahi Department of Medical Physics, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran 2021 04 04 2021 07 18 Background: Contact dermatitis (CD) is a common inflammatory disease of the skin. CD has a complex and multifaceted treatment, and one of the main components of CD treatment is inflammation management. We summarized the clinical trials exploring the effects of herbal medicine on patients with CD. Methods: A systematic review was performed by searching four databases. Clinical trials in English investigating the effect of herbal medicines on CD prevention and treatment published from 2010 to 2020 were reviewed. This study was conducted based on the PRISMA guidelines. Results: Nine clinical trials examining the effects of herbs on CD were identified. A total of 450 patients participated in these studies. Herbal medicines used in the reviewed studies were in various forms. Almost all the studies showed that these herbs were useful in preventing and treating CD. Regarding the side effects of the herbal medicines, few complications such as erythema and papules as well as positive chronotropic effects were reported. Conclusion: Evidence showed that herbal medicines were effective in preventing and treating CD by reducing the inflammation level and increasing antioxidant defense. However, the number of clinical trials was low to draw definitive conclusions. Moreover, the studies were not homogeneous and differed regarding methodology, evaluation tools, and quality. Also, in these studies, the interactions and safety of the herbal medicines were not considered adequately. Therefore, well-designed evidence is required to draw definitive conclusions in this regard. https://ijph.tums.ac.ir/index.php/ijph/article/view/24430 https://ijph.tums.ac.ir/index.php/ijph/article/download/24430/7615