Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 51 5 2022 05 08 967 977 Norfazilah Ahmad Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia Azmawati Mohammed Nawi Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia Mohd Nazrin Jamhari 1. Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia 2. Ministry of Health, Malaysia, Federal Government Administrative Centre, 62590 Putrajaya, Malaysia Siti Nurumal 1. Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia 2. Ministry of Health, Malaysia, Federal Government Administrative Centre, 62590 Putrajaya, Malaysia Juliana Mansor 1. Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia 2. Ministry of Health, Malaysia, Federal Government Administrative Centre, 62590 Putrajaya, Malaysia Mohd ‘Ammar Ahmad Zamzuri 1. Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia 2. Ministry of Health, Malaysia, Federal Government Administrative Centre, 62590 Putrajaya, Malaysia Teh Li Yin 1. Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia 2. Ministry of Health, Malaysia, Federal Government Administrative Centre, 62590 Putrajaya, Malaysia Mohd Hassan Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia 2. Department of Pharmacy, Hospital Tuanku Ja’afar, Seremban, Negeri Sembilan, Malaysi 2021 02 27 2021 06 21 Background: Post-exposure prophylaxis (PEP) is an effective method for preventing rabies, a highly fatal infection in exposed persons. Malaysia is currently using the purified Vero cell rabies vaccine (PVRV). Nonetheless, there are other commercially available vaccine types and regimens. This systematic review aimed at comparing the effectiveness of the different PEP vaccines, regimens and routes of administration among Asian populations. Methods: We systematically reviewed the PubMed and Web of Science databases for articles reporting on the effectiveness of PEP vaccination against rabies among Asian populations between 2015 and 2019. Results: Our search identified 11 relevant studies. Majority of study either used PCECV or PVRV type of vaccine, with different regimes and method. All are non-inferior to the other. Most of the studies recorded adequate response by Day 14 of vaccination. Nonetheless, the intradermal (ID) vaccination used minimal volume of vaccine used in all settings, thus cost less and the concurrent administration of RIG to the wound(s) doesn’t affect the RVNA GMT response. Conclusion: PCECV, using either the Essen or Zagreb regimen, might be a useful alternative for the healthy population in the context of PVRV shortage, especially during an outbreak. Use of the Zagreb or Thai Red Cross (TRC) regimens can be considered (either PVRV or PCECV), as both demonstrate good immunogenic outcomes in Asian populations. https://ijph.tums.ac.ir/index.php/ijph/article/view/24011 https://ijph.tums.ac.ir/index.php/ijph/article/download/24011/7583