Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 7 2021 07 01 Prehospital Management and Transportation Strategies for Handling COVID-19 Cases 1483 1485 Chen Li Medical Service Department, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China Lei Wei Medical Service Department, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China Junyuan Tan Medical Service Department, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China Xinglong Yang Medical Service Department, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China 2021 02 20 2021 03 06 none https://ijph.tums.ac.ir/index.php/ijph/article/view/23937 https://ijph.tums.ac.ir/index.php/ijph/article/download/23937/7294
hip between PTPN22 genetic polymorphisms and JIA risk from PubMed and Embase databases. Overall, 4552 cases and 10161 controls were investigated in this study to evaluate the association between PTPN22 (C allele vs. T allele) genotype and JIA susceptibility. Results: Analysis using random effects model showed an increased risk of JIA with T allele of rs2476601 vs. A allele (P<0.001). Subgroup analysis suggested that the PTPN22 polymorphism (1858C＞T) was significantly associated with JIA risk in America population (OR=1.52, 95%CI:1.30-1.78). Additionally, the subgroup analysis also showed that the associations were still significant in case number more than 500 (OR=1.38, 95% CI: 1.04-1.83), while in the case number less than 500 was OR=1.55, 95% CI: 1.39-1.72. Conclusions: SNPs of PTPN22 (1858C＞T) showed an increased risk of developing JIA.     https://ijph.tums.ac.ir/index.php/ijph/article/view/3386 https://ijph.tums.ac.ir/index.php/ijph/article/download/3386/3095