Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 7 2021 07 01 1343 1351 Hailing Yang Nursing Department, Qilu Hospital of Shandong University, Jinan 250012, P.R. China Meimei Shang Nursing Department, Shandong Cancer Hospital and Institute, Jinan 250117, P.R. China Chunhua Sun Health Manage Department, Qilu Hospital of Shandong University, Jinan 250012, P.R. China Lihua Li Urology Surgery Department, The Third Affiliated Hospital of Shandong Province, Jinan 250031, P.R. China Chao Wang Outpatient Department, Qilu Hospital of Shandong University, Jinan 250012, P.R. China 2021 02 04 2021 03 06 Background: Palliative care is an essential part of medical practice, however, it has developed slowly in China. We aimed to analyze the current situations of the cognition on palliative care among the nurses in Shandong Province, China. Methods: This was a cross sectional study. Investigation of 1050 nurses came from 5 third-class hospitals and 5 second-class hospitals in Shandong Province, China from Jul to Oct in 2018. The questionnaire included 4 parts: general information of the subject, the questionnaire of palliative nursing knowledge, attitude, and the behavior. Data were collected by the APP. Overall, after eliminating the invalid questionnaires, 1026 questionnaires were included in the final analyses. The software Stata 14.2 was used for all statistical analyses. Results: The score of knowledge and attitude was low, the practice was higher. Multivariate analysis results: the significant independent variables of univariate analysis were included in the multivariate non-conditional logistic regression model for analysis. Some departments had statistical significance in knowledge multivariate Logistic regression analysis. The multivariate logistic regression analysis of practice was significant for physical health and religious beliefs. The statistical variables of the total score of cognition were gender, age of care, health status and religious beliefs. Conclusion: Nursing knowledge is lacking and attitude remains to be improved as soon as possible. It is vital to improve the cognition of palliative care of nurses in Shandong general hospitals by developing relevant rules and regulations, strengthening the supervision of relevant ant departments, and enhancing training for nurses. https://ijph.tums.ac.ir/index.php/ijph/article/view/23753 https://ijph.tums.ac.ir/index.php/ijph/article/download/23753/7278