Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 51 9 2022 09 04 2078 2088 Xuan Zhong 1. Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China 2. School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China Hui Wang Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China Chun Chen Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China Xiaoni Zou Guangdong Women and Children Hospital, Guangzhou 510010, China Tiegang Li Guangzhou Municipal Health Commission, Guangzhou 510062, China 2021 01 13 2021 07 01 Background: Hand, foot and mouth disease (HFMD) reinfection is common because of the limited cross-protection from infections of different enterovirus. We aimed to investigate the epidemiological characteristics and its influential factors of HFMD reinfection in Guangzhou, China. Methods: Data on HFMD patients aged ≤5 yr from 2012 to 2017 were extracted from surveillance system. Influential factors of reinfection were assessed using the logistic regression model. Results: Of 369,054 HFMD patients, 11,321 patients (3.07%) were classified as reinfection. The reinfection rate in male was higher than in female (χ2=60.11, P<0.001). The reinfection rate in patients ≤1 yr was 3.86%, which showed a downward trend with age (Z=37.37, Ptrend<0.001). The highest reinfection rate was observed in the scattered children (3.38%), followed by nursery care children and others (χ2=514.75, P<0.001). Besides, higher risk of reinfection was detected among those who were male, lower age group, rural residence and other enteroviruses infection compared with their respective counterparts. Seasonality was illustrated according to the number of reinfections peaked from April to July. Time intervals curves revealed the number of reinfections gradually increased after 13 months from the initial infection. Conclusion: Male ≤4 yr, living rural area, especially those lived scattered and infected with other enteroviruses were more likely to be reinfection. https://ijph.tums.ac.ir/index.php/ijph/article/view/23480 https://ijph.tums.ac.ir/index.php/ijph/article/download/23480/7721