Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 4 2021 04 05 721 727 Hümeyra Aslaner Kayseri City Hospital, Family Medicine, Kayseri, Turkey Hacı Ahmet Aslaner İncesu County State Hospital, Internal Medicine, Kayseri, Turkey Mebrure Beyza Gökçek Health Directorate of Kayseri, Kayseri, Turkey Ali Ramazan Benli Health Directorate of Kayseri, Kayseri, Turkey Orhan Yıldız Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Erciyes University, Kayseri, Turkey 2021 01 04 2021 01 25 Background: We aimed to reveal how chronic diseases, age and gender affected morbidity and mortality in patients with Coronavirus disease of 2019 (COVID-19). Methods: Medical records of all reverse transcription polymerase chain reaction (RT-PCR) positive COVID-19 patients followed up in hospital and home isolation between 13th of Mar 2020 and 12th of May 2020 were retrospectively reviewed. The patients were from Kayseri Province, Turkey. Patients’ demographic and clinical characteristics and the factors associated with morbidity and mortality were analyzed. Results: Of all the patients, 773 (95.8%) were alive and 34 (4.24%) died. The fatality rate was 4.2%. There were differences between the age groups in terms of fatality rate (P<0.001). The fatality rate in patients above the age of 65 yr was significantly higher. The fatality rate in the male gender was 2.44 times higher (P<0.05). It was 1.104 times higher in advanced age (P<0.001) and 10.893 times higher in patients with at least one comorbid disease (P<0.05). Hypertension increased mortality by 3.635 times (P<0.05) and chronic pulmonary diseases by 2.926 times (P<0.05). Conclusion: Advanced age, male gender and accompanying chronic diseases have adverse effects on the course and severity of the disease and hospitalization. They also increased the rate and risk of mortality. https://ijph.tums.ac.ir/index.php/ijph/article/view/23382 https://ijph.tums.ac.ir/index.php/ijph/article/download/23382/7190