Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 4 2021 04 05 665 675 Mahdi Zavvar Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Hamid Emadi Kochak Department of Infectious Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Kamal Abdolmohammadi Department of Medical Laboratory Sciences, Sari Branch, Islamic Azad University, Sari, Iran Nesa Rashidi 1. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran 2. Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran Majid Mokhtari Department of Medicine, Pulmonary & Critical Care Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Farshid Noorbakhsh Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Kayahan Azadmanesh Department of Virology, Pasteur Institute of Iran, Tehran, Iran Ehsan Shamsi Gooshki Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran Yousef Fatahi 1. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran 2. Nanotechnology Research Center, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Talat Mokhtari Azad Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Alireza Jahangirifard Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti Universi-ty of Medical Sciences, Tehran, Iran Mohammad Javad Mousavi Department of Hematology, School of Allied Medicine, Bushehr University of Medical Sciences, Bushehr, Iranof Elham Masoumi Department of Medical Immunology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran 2. Zoonotic Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran Hamid Reza Mirzaei Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Mohammad Mahdi Gouya Communicable Disease Control Centre, Ministry of Health and Medical Education, Tehran, Iran Farshid Rezaei Communicable Disease Control Centre, Ministry of Health and Medical Education, Tehran, Iran Mohammad Hossein Nicknam Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran 2020 11 04 2020 11 08 In the last two decades, we have witnessed three major epidemics of the coronavirus human disease namely, severe acute respiratory syndrome (SARS), Middle Eastern respiratory syndrome, and more recently an ongoing global pandemic of coronavirus disease 2019 (COVID-19). Iran, a country of nearly 84 million, in the Middle East, severely involved with the COVID-19 disease. A documented multidimensional approach to COVID-19 disease is therefore mandatory to provide a well-balanced platform for the concerned medical community in our county and beyond. In this review, we highlight the disease status in Iran and attempt to provide a multilateral view of the fundamental and clinical aspects of the disease including the clinical features of the confirmed cases, virology, pathogenesis, epidemiology, and laboratory methods needed for diagnosis. https://ijph.tums.ac.ir/index.php/ijph/article/view/22751 https://ijph.tums.ac.ir/index.php/ijph/article/download/22751/7185