Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 51 2 2022 02 06 278 291 EN Maryam Emadzadeh Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Atieh Mehdizadeh Department of Clinical Nutrition, Qaem Educational, Research and Treatment Center, Mashhad University of Medical Sciences, Mashhad, Iran Payam Sharifan Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mahdieh Khoshakhlagh Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Reza Sahebi 1. Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 2. Department of Molecular Medicine, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran Ramin Sadeghi Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Gordon A. Ferns Brighton & Sussex Medical School, Division of Medical Education, Brighton, UK Majid Ghayour-Mobarhan Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 2020 11 02 2021 04 02 Background: Vitamin D plays an essential role in the regulation of bone metabolism. The current meta-analysis aimed to assess the effectiveness of vitamin D fortification on special bone biomarkers. Methods: Five main databases (PubMed/Medline, ISI Web of Knowledge, Science Direct, Scopus, Cochrane Library as well as Science Direct, and Scopus) were considered for this systematic review, until Jan 2020. All randomized controlled trials were included to evaluate the probable relationship between consumption of vitamin D fortification products and bone biomarkers profile in this review. Results: Among serum bone biomarkers (osteocalcin and telopeptides of type-1 collagen) investigated, only the level of telopeptides of type-1 collagen significantly decreased after fortification of vitamin D in the intervention group. A significant increase in vitamin D was seen in those older than 18 yr old, while the increase in younger children was not statistically significant between intervention and control groups. Conclusion: Vitamin D fortification was not associated with a significant improvement in bone mass density (BMD), while it resulted in decreased PTH levels. Vitamin D fortified foods have some benefits on bone health due to increase in the level of vitamin D and IGF-1; and decreasing PTH and CTx levels. https://ijph.tums.ac.ir/index.php/ijph/article/view/22726 https://ijph.tums.ac.ir/index.php/ijph/article/download/22726/7494