Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 51 6 2022 06 08 1371 1380 EN Maryam Askari 1. Genetic and Environmental Adventures Research Center, School of Abarkouh Paramedicine, Shahid Sadoughi University of Medi-cal Sciences, Yazd, Iran 2. Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mohammad Hassan Lotfi Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Seyyed Mohammad Azimi Department of Occupational Health, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Abarkouh, Yazd, Iran Maral Ostovarfar Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Hossein Fallahzadeh Research Center of Prevention and Epidemiology of Non-Communicable Disease, Departments of Biostatistics Nand Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Akram Mehrabbeik Genetic and Environmental Adventures Research Center, School of Abarkouh Paramedicine, Shahid Sadoughi University of Medi-cal Sciences, Yazd, Iran Andishe Hamedi Faculty of Epidemiology & Biostatistics, Imam Khomeini Hospital, North Khorasan University of Medical Sciences, Bojnurd, Iran 2020 10 18 2021 02 07 Background: The aim of this study was to evaluate the predictors of osteoporosis in women in Yazd, Iran. Methods: This hospital-based case-control study was performed on 270 women 35-65 yr old (135 case and 135 control) from Mar 2016 to Mar 2017. Case and control were matched in terms of age ± 2 (year) as a group matching. Osteoporosis is defined as a T-score of bone mineral density (BMD) below –2.5 SD. Data were analyzed using SPSS 20 software. Statistical tests included chi-square, student t test and Mann Whitney test .Multiple logistic regression (MLR) which forward method was used for modeling. Results: Odds ratio (OR) of osteoprosis were menarche age>12 yr (OR=3.37, CI:2.29-15.89), history of hysterectomy (OR=13, CI:3.81-44.82), rheumatoid arthritis (RA) (OR=6.58, CI:2.29-18.91) calcium supplements (OR=0.14, CI:0.04-0.41), menopause age <40 (OR=11.84, CI:1.54-90), second smoking (OR=3.38, CI:1.16-9.81) and increase of weight (OR=0.86, CI:0.80-0.94). Conclusion: Predictors of osteoporosis was menarche age >12 yr (3 times), history of hysterectomy (13 times), RA (6.5 times), menopause age <40 (12 times), second smoking (more than 3 times), calcium supplements and weight (protective).   https://ijph.tums.ac.ir/index.php/ijph/article/view/22549 https://ijph.tums.ac.ir/index.php/ijph/article/download/22549/7633