Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 12 2020 11 29 339 2347 Changqing SUN Department of Internal Medicine, Weifang People's Hospital Brain Hospital, Weifang 261021, P.R. China Xiulin LI Electrocardiographic Room, Weifang People's Hospital Brain Hospital, Weifang 261021, P.R. China Daoqing WANG Department of Internal Medicine, Weifang Weicheng People's Hospital, Weifang 261041, P.R. China Liming WANG Department of Intensive Care Unit, Weifang People's Hospital, Weifang 261000, P.R. China 2020 07 16 2020 08 20 Background: To investigate the therapeutic and diagnostic value of caspase-12 and study of growth differentiation factor-15 (GDF-15) in patients with acute myocardial infarction (AMI). Methods: Overall 78 patients with AMI admitted to Weifang People's Hospital Brain Hospital, Weifang, China from Apr 2016 to Apr 2019 were enrolled as AMI group. Seventy five non-AMI people undergoing physical examination during the same period were enrolled as non-AMI group. The expression levels of caspase-12 and GDF-15 were detected and compared. The correlation between the expressions of GDF-15, caspase-12 and clinical characteristics and efficacy was detected. Single and combined detection of GDF-15 and caspase-12 were performed analyze their role in the early diagnosis, the prediction of efficacy, and the guidance of clinical therapy. Results: After treatment, the levels of GDF-15 and caspase-12 in AMI group were significantly lower than those before treatment (P<0.001). The expression levels of GDF-15 and caspase-12 were significantly correlated with blood pressure (P<0.05). The expression levels of GDF-15 and caspase-12 were significantly negatively correlated with clinical efficacy in AMI group. The diagnostic value of combined detection of GDF-15 and caspase-12 was higher than that of single diagnosis. The levels of serum caspase-12 and GDF-15 proteins were significantly up-regulated in AMI patients. With the better therapeutic effect, the levels of serum caspase-12 and GDF-15 proteins decreased significantly. Conclusion: The levels of serum caspase-12 and GDF-15 proteins may be a key indicator in the clinical diagnosis of acute myocardial infarction and may also be used to guide the treatment of AMI patients and predict the therapeutic efficacy. https://ijph.tums.ac.ir/index.php/ijph/article/view/21502 https://ijph.tums.ac.ir/index.php/ijph/article/download/21502/7070