Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 37 3 2008 09 15 1 8 DD Farhud Genetic Clinic, Vallie Assr Sq, 16 Keshavarz Blvd, Tehran 14, Iran M Asghari Dept. of Nutrition, Iran University of Medical Science, Iran H Sadighi Genetic Clinic, Vallie Assr Sq, 16 Keshavarz Blvd, Tehran 14, Iran 2015 10 03 Collection of multiple processes that increase the chronological age of an organism leading to death is defined as aging, and even though important, it is poorly understood. Recent research has shown that aging is due to biochemical and genetic changes, in interaction with environmental effects, including diet and nutrition. Most knowledge on aging is based on ge­netic model system, but its molecular mechanisms are still not very clear. Discoveries in molecular biology have made way to look for candidate genes influencing lifespan. Furthermore, new investigations have stressed on the roles of mitochondria as the major generators and direct targets of reactive oxygen species. This paper reviews some recent literature on genes and ag­ing in model system, then discusses the role of mitochondria and nutrients in human aging. https://ijph.tums.ac.ir/index.php/ijph/article/view/2028 https://ijph.tums.ac.ir/index.php/ijph/article/download/2028/2009