Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1439 1446 Yiyu YIN Department of General Surgery, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. China Xiaole WU Department of Anesthesiology, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. China Huaxin ZOU Department of General Surgery, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. China Shixian LI Department of General Surgery, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. China Zhenfang QIN Department of General Surgery, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. China Tengfei ZHANG Department of General Surgery, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. China Junhua CAO Department of Emergency Medicine, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. China 2020 03 10 2020 06 24 Background: To investigate the expressions of fibrinogen (Fib) and Interleukin-12 (IL-12) in serum of neonatal necrotizing enterocolitis (NEC), and to analyze the correlation between the two and their relationship with clinicopathological features. Methods: Forty two children with NEC treated in Xuzhou Children’s Hospital, Xuzhou Medical University Xuzhou, China from 2016-2019 were selected as an observation group and 40 children who underwent physical examination at the same period as a control group. The expression levels of Fib and IL-12 in the serum of two groups were detected by ELISA. The correlation between Fib and IL-12 in the observation group and the correlation among the expressions of Fib, IL-12, the clinicopathological features and common examination indexes of the children with NEC were investigated by Pearson correlation analysis. Results: The levels of Fib and IL-12 in the serum of the children in observation group were significantly higher than those in the control group were (P<0.05). There was a significant positive correlation between the levels of Fib and IL-12 in the serum of the children in observation group (P<0.05). The expression levels of Fib, IL-12 were not significantly correlated with sex and age of NEC children, but correlated with vomiting, diarrhea, bloody stool and bradycardia in NEC children (P<0.05). Fib and IL-12 were positively correlated with erythrocyte level (P<0.05) and negatively correlated with platelet level. Conclusion: The expressions of Fib and IL-12 in the serum of NEC children can objectively predict the severity of NEC. https://ijph.tums.ac.ir/index.php/ijph/article/view/20013 https://ijph.tums.ac.ir/index.php/ijph/article/download/20013/6937