Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 3 2020 03 01 463 471 Hongliang LIU Department of Cardiology, Lianshui County People's Hospital, Huaian 223400, P.R. China Hao QIAN Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, 210000, P.R. China Junlin MA Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, 210000, P.R. China Qiming DAI Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, 210000, P.R. China Mingyue JI Department of Cardiology, Lianshui County People's Hospital, Huaian 223400, P.R. China 2020 03 01 Background: To explore the changes of miR-130a and endothelin -1 (ET-1) and their predictive value for in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). Methods: Overall, 253 patients with coronary heart disease (CHD) treated with PCI in Lianshui County People's Hospital, Huaian, China from April 2013 to May 2016 were selected. The changes of miR-130a and ET-1 levels before and after PCI were compared. The predictive value of miR-130a and ET-1 for ISR was analyzed by receiver operating characteristic (ROC) curves, and the correlation between ISR and miR-130a, ET-1 was analyzed by Kaplan-Meier (K-M) curve. The risk factors of ISR in CHD patients were evaluated by logistics regression analysis. Results: The postoperative levels of miR-130a and ET-1 were significantly increased (P<0.05). The levels of miR-130a and ET-1 in peripheral blood of patients with ISR were higher than those in patients without ISR (P<0.05). The ROC curves showed that the area under curve (AUC), sensitivity, specificity and critical value of miR-130a in predicting ISR were respectively 0.912, 92.02%, 73.47%, 1.457 pmol/L, and those of ET-1 were 0.814, 87.63%, 63.27%, 2.245 pmol/L, respectively. The K-M curve showed that the incidence of ISR in patients with high expression of miR-130a or ET-1 was significantly higher than that in patients with low expression (P<0.05). miR-130a and ET-1 were independent risk factors for ISR (P<0.05). Conclusion: MiR-130a and ET-1 have high predictive value for ISR after PCI and are independent risk factors for CHD patients, which are worthy of clinical application. https://ijph.tums.ac.ir/index.php/ijph/article/view/19872 https://ijph.tums.ac.ir/index.php/ijph/article/download/19872/6693