Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 2 2020 02 01 386 388 Faten HADJ KACEM Department of Endocrinology, Hedi Chaker Hospital, Sfax, Tunisia Donia CHEBBI Department of Endocrinology, Hedi Chaker Hospital, Sfax, Tunisia Amal CHAKROUN Department of Endocrinology, Hedi Chaker Hospital, Sfax, Tunisia Nadia CHARFI Department of Endocrinology, Hedi Chaker Hospital, Sfax, Tunisia Dorra GHORBEL Department of Endocrinology, Hedi Chaker Hospital, Sfax, Tunisia Fatma MNIF Department of Endocrinology, Hedi Chaker Hospital, Sfax, Tunisia Mouna MNIF Department of Endocrinology, Hedi Chaker Hospital, Sfax, Tunisia Nabila REKIK Department of Endocrinology, Hedi Chaker Hospital, Sfax, Tunisia Mohamed ABID Department of Endocrinology, Hedi Chaker Hospital, Sfax, Tunisia 2020 01 29 VIPoma is an unusual neuroendocrine neoplasm that autonomously secretes VIP. It is associated with secretory diarrhea and electrolyte disturbances. Herein we report a case of a male patient, who was hospitalized in the Department of Endocrinology in Hedi Chaker Hospital, Sfax, Tunisia. He presented VIPoma syndrome, with hepatic metastases at diagnosis. He had a history of chronic, watery diarrhea. He was dehydrated with many electrolytic disorders as hypokalemia, hyponatremia and metabolic acidosis. Abdominal CT scan showed a heterogeneous mass in the pancreatic head with multiple hepatic lesions. A high VIP hormone level was found. Histological study of a liver biopsy revealed hepatic metastases of neuroendocrine carcinoma. The patient received analogues of somatostatin and systemic chemotherapy, with a transient symptomatic relief. Sadly the patient was lost to follow-up. https://ijph.tums.ac.ir/index.php/ijph/article/view/19593 https://ijph.tums.ac.ir/index.php/ijph/article/download/19593/6677