Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 9 2019 09 03 1697 1703 Sima SABBAGH Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Zakiye NADEALI Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran AND Medical Genetics Laboratory, Al-Zahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran Leila DEHGHANI Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti Uni-versity of Medical Sciences, Tehran, Iran Vahid SHAYGANNEJAD Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Majid REZVANI Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Masih SABOORI Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Hamid GANJI Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Soheil TAHANI Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Farzaneh DEHGHANI Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Saman HOSSEINZADEH Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Elnaz MARZBANI Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Peiman SHAFIEI Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran 2019 09 03 Background: Matrix metalloproteinase-9 (MMP-9) polymorphisms, C−1562 T and -90 (CA) n repeats, which influence transcriptional activity of this gene, are proposed to play a role in MS susceptibility and its development. In the present study, the possible association of MMP-9 polymorphisms in Iranian MS patients is studied. Methods: Association of MMP-9 mentioned gene polymorphisms with MS susceptibility was evaluated in unrelated Iranian subjects referred to Al-Zahra Hospital, Isfahan, Iran during 2014 to 2017.  Results: -1562 T allele of MMP-9 was associated with increased MS risk. However, we found no overall significant effect of −90 (CA)n repeat on MS susceptibility. Conclusion: For as much as MMP-9 molecule is a potential target for MS therapy, to determine whether any of MMP-9 polymorphisms influence MS susceptibility in Iranian MS patients or not, concerning the significant influence of T allele on MS susceptibility and the non-significant association regarding CA repeats, further research is needed before proposing any definite conclusion.   https://ijph.tums.ac.ir/index.php/ijph/article/view/18257 https://ijph.tums.ac.ir/index.php/ijph/article/download/18257/6509