Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 7 2019 07 01 1369 1374 Mirsajjad MOUSAVI-ASL GERMEH CHESHMEH Student Research Committee, Ardabil University of Medical Sciences, Ardabil, Iran Ali NAJIZADEH Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran Saied HOSSEINI-ASL Homa Gene Clinic, Department of Genetics, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran Hooshang ZAIMKOHAN Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran AND Department of Biochemistry, Genetics and Nutrition, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran Roshanak JAZAYERI Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran AND Department of Biochemistry, Genetics and Nutrition, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran 2019 06 27 Congenital Nail abnormalities are rare ectodermal defects. Autosomal recessive nail dysplasia is much rarer. Recently it has been recognized as a condition resulting in nail dystrophy in the absence of other cutaneous or extracutaneous disorders. Few case reports have identified mutations in the Frizzled 6 (FZD6) gene in families presenting with abnormal nails consistent with Non-Syndromic Congenital Nail Dysplasia. We report a family presenting, they lived in Namin a country of the Ardabil Province, northwestern Iran in 2016, for the first time in Iran in whom we identified mutations in FZD6 with abnormal nails formation.     https://ijph.tums.ac.ir/index.php/ijph/article/view/17599 https://ijph.tums.ac.ir/index.php/ijph/article/download/17599/6455