Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 6 2019 06 03 1133 1139 Farhad SHAHRAM Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Javad KAZEMI Department of Clinical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran Mahmoud MAHMOUDI Department of Biostatics and Epidemiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Zohreh JADALI Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2019 06 03 Background: Both genetic and environmental factors influence, susceptibility to autoimmune disorders including Behcet’s disease (BD). FCRL3 (Fc receptor like 3 genes), a novel immunoregulatory gene, has recently been reported as a new promising candidate gene for general autoimmunity. This study was conducted to explore the potential association of FCRL3 polymorphisms with BD. Methods: This study was conducted from 2010 to 2015 in Tehran University of Medical Sciences, Tehran, Iran. Four single-nucleotide polymorphisms of FCRL3 (rs7528684, rs11264799, rs945635, and rs3761959) were genotyped in 220 patients and 220 healthy controls. Typing of the polymorphisms in this case-control study was carried out using polymerase chain reaction-restriction fragment length polymorphism analysis. Results: Analysis of the alleles revealed a significantly lower frequency of the A allele at the -169 site (rs7528684) in BD patients compared with that in controls (P=0.000, 66.4% versus 82%, χ2= 30.23). Moreover, a significant lower frequency of AA genotype and higher frequency of GG genotype was recorded for rs7528684. There was also relationship between posterior uveitis as a clinical sign of disease and polymorphism of allele A at the -169 site (P=0.015). Conclusion: This study revealed a significant difference in both allele and genotype frequency at position -169 of FCRL3 gene between Iranian patients with BD and normal subjects. These data suggest FCRL3 gene polymorphisms might be the autoimmunity risk factor for BD.   https://ijph.tums.ac.ir/index.php/ijph/article/view/17360 https://ijph.tums.ac.ir/index.php/ijph/article/download/17360/6420