Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 5 2019 05 14 841 848 Rong GUI The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Xueyuan HUANG The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Ming ZHOU Department of Hematology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China Shujuan OUYANG The Hunan Cancer Hospital, Changsha, Hunan , China Yunfeng FU The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Hao TANG The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Fengxia LIU The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Rong HUANG The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Meng GAO The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Hang DONG The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Yongjun WANG The Second Xiangya Hospital, Central South University, Changsha, Hunan, China 2019 05 14 Background: We aimed to establish the reference range of thrombelastogram (TEG) for Chinese healthy volunteers and pregnant women and analyze the influence factors. Methods: Blood samples were collected from healthy volunteers and pregnant women at five tertiary hospitals (the Third Xiangya Hospital of Central South University, the Second Xiangya Hospital of Central South University, Hunan Provincial People's Hospital, Hunan Cancer Hospital and Changsha Central Hospital) in 2016. The effects of age, gender, blood type, and full-term pregnancy on the reference range of normal TEG for healthy volunteers and pregnant women were studied. The specificity of TEG in detecting coagulation disorder. Results: For healthy volunteers, the normal ranges of TEG parameters were as follows: R, 4.3-9.3 min; K, 1.2-3.2 min; α, 50.2-71.2°; MA, 54.1-71.3 mm; LY30: 0%-2.2%; CI, -3.8-2.4. At least one parameter exceeded the normal range specified by the manufacturer in 20.3% of the healthy volunteers; about 7.6% healthy volunteers were diagnosed as coagulation disorder by the above standards; the specificity of detection was 79.7%. There were significant differences in R, K, α, MA and CI between males and females (P<0.01). For pregnant women, the normal ranges of TEG were as follows: R, 3.9-7.5 min; K, 1.0-2.4 min; α, 57.6-74.9°; MA, 55.7-75.7 mm; LY30, 0%-0.56%; CI, -0.97-3.6. Pregnant women having O blood group had a dramatically prolonged R. Full-term pregnancy had no significant impact on TEG results. Conclusion: Compared with pregnant women having non-O blood group, those having O blood group had a dramatically prolonged R and showed greater tendency to hemorrhage during and after parturition.     https://ijph.tums.ac.ir/index.php/ijph/article/view/17110 https://ijph.tums.ac.ir/index.php/ijph/article/download/17110/6379