Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 3 2019 03 12 379 387 Wenwen XUE Key Laboratory of Biomedical Engineering & Technology, Qilu Medical University, Zibo, China AND Department of Biomedical Engineering, College of Engineering, University of North Texas, TX, USA Jing YOU Department of Biomedical Engineering, College of Engineering, University of North Texas, TX, USA Yingchao SU Department of Biomedical Engineering, College of Engineering, University of North Texas, TX, USA Qinglu WANG Key Laboratory of Biomedical Engineering & Technology, Qilu Medical University, Zibo, China AND college of Life Science, Shandong Normal University, Jinan, China 2019 03 12 Background: Magnesium (Mg) is an essential element for the body. It is a cofactor for ATP, DNA, and RNA and more than 600 enzymes. As it is similar to Ca2+, this element can also act as a cell signaling molecule and play multiple important roles in the nervous, muscle, and immune systems. Recent studies have associated Mg-deficiency with many neurological disorders, such as cerebral vasospasm, Alzheimer’s disease, stroke, and migraine. As it plays such a crucial role in human body, therefore, we summarized the role of Mg in neurological disorders to illustrate the symptoms caused by Mg-deficiency and the possible underlying mechanisms. Methods: We critically discuss the role of it that we review the recent literature of magnesium. We also review the available data which are concerning the role of magnesium in neurological disorders. Results: Magnesium is related to neurological disorders on the basis of the study of animals and humans experiments. Furthermore, these nervous systems related diseases include cerebral vasospasm, Alzheimer’s disease, Parkinson’s disease, stroke and migraine. Conclusion: Magnesium has effects on neurological disorders, such as its utility in cerebral vasospasm, Alzheimer’s disease, Parkinson’s disease, stroke and migraine. So here we make a brief review to conclude it.     https://ijph.tums.ac.ir/index.php/ijph/article/view/16507 https://ijph.tums.ac.ir/index.php/ijph/article/download/16507/6315