Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 2 2019 02 01 206 216 Maedeh SHARGHI Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran Hadis MUSAVI Student Research Committee, Babol University of Medical Sciences, Babol, Iran Shabnam MALEKPOUR MANSURKHANI Department of Biology, School of Sciences, Shiraz University, Shiraz, Iran Wesam KOOTI Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran Masoud BEHZADIFAR Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran Hadis ASHRAFI-ZADEH Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Milad AZAMI Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Roonak SHAHOOEI Clinical Care Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran Hajar KASHEFI Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran Leila JOUYBARI Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran 2019 02 05 Background: Human cytomegalovirus (CMV) able to cause infection for an entire lifetime. This systematic review and meta-analysis was conducted to determine seroprevalence of CMV among women of reproductive age in Iran. Methods: English and Persian databases such as Web of Science (WOS), PubMed, Scopus, Cochrane Library, SID, Iran doc, Iran Medex, Magiran, and Medlib were searched (from 2008 to 2017) accurately using the Results: Results of 15 studies with total samples of 5253 persons from 2008 to 2017 were combined and meta-analyzed. The pooled prevalence rate of IgG among women was estimated 90% (95% CI: 87-93%). The highest prevalence rate of IgG was in Tehran, Rasht, Mashhad and Yasoj, all 100% (95% CI: 100-100%), and the lowest prevalence was in Jahrom 0.62% (95% CI: 53-71%). The overall prevalence rate of IgM among women was estimated at 0.06% (95% CI: 0.03-0.13%). The highest prevalence rate of IgM was in Kerman 0.34% (95% CI: 0.29-0.39%) and Mashhad 0.25% (95% CI: 0.2-0.31%), and the lowest prevalence was in Yasoj 0% (95% CI: 0.00%-0.00%) Conclusion: The prevalence of immunity in Iran, is satisfactory. Nevertheless, to maintain and increase the level of immunity across the country, it is necessary to routinely screen the women of reproductive ages across the country. https://ijph.tums.ac.ir/index.php/ijph/article/view/16139 https://ijph.tums.ac.ir/index.php/ijph/article/download/16139/6277