Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 2 2019 02 05 189 197 Zhaowei ZHANG Department of Pharmacy, Jin Hua Municipal Central Hospital, Jin Hua 32100, China Chunlin CHEN College of Chemistry and Bio-Engineering, Yi Chun University, Yi Chun 336000, China Shiwen LV Department of Pharmacy, Jin Hua Municipal Central Hospital, Jin Hua 32100, China Yalan ZHU Department of Pharmacy, Jin Hua Municipal Central Hospital, Jin Hua 32100, China Tianzi FANG Department of Pharmacy, Jin Hua Municipal Central Hospital, Jin Hua 32100, China 2019 02 05 Background: The angiotensin-converting enzyme inhibitors (ACEIs) could improve the symptoms of diabetic nephropathy. Whether the calcium channel blockers (CCBs) could be as effective as ACEIs on treating diabetic nephropathy is controversial. Here, we aimed to compare the efficacy of ACEIs with CCBs on the treatment of diabetic nephropathy by performing a meta-analysis of randomized controlled trials (RCTs). Methods: The Pubmed, Medline, Embase and The Cochrane Database were searched up to July 2017 for eligible randomized clinical trials studies. Effect sizes were summarized as mean difference (MD) or standardized mean difference (SMD) with 95% confidence intervals (P-value<0.05). Results: Seven RCTs involving 430 participants comparing ACEIs with CCBs were included. No benefit was seen in comparative group of ACEIs on systolic blood pressure（SBP） (MD=1.05 mmHg; 95% CI: -0.97 to 3.08, P=0.31), diastolic blood pressure (DBP) (MD= -0.34 mmHg; 95% CI: -1.2 to 0.51, P=0.43), urinary albumin excretion rates (UAER) (MD=1.91μg/min; 95% CI: -10.3 to 14.12, P=0.76), 24-h urine protein (24-UP) (SMD=-0.26; 95%CI: -0.55 to 0.03, P=0.08), glomerular filtration rate (GFR) (SMD=0.01; 95% CI: -0.38 to 0.41, P=0.95). On safety aspect, the risk of adverse reactions between ACEIs group and CCBs group are similar (RR=1.18; 95% CI: 0.61 to 2.28; P=0.61). Conclusion: Both ACEIs and CCBs could improve the BP, UAER, 24h-UP, and GFR of diabetic nephropathy to a similar extent.     https://ijph.tums.ac.ir/index.php/ijph/article/view/16137 https://ijph.tums.ac.ir/index.php/ijph/article/download/16137/6275