Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 1 2020 12 28 146 151 Hossein SEDAGHAT Department of Microbiology, Faculty of Medicine, Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran Tahmineh NARIMANI Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Bahram NASR ESFAHANI Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Sina MOBASHERIZADEH Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Seyed Asghar HAVAEI Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran AND Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 2018 11 28 2019 06 03 Background: Staphylococcus aureus (S. aureus) is one of the most important pathogens in burn infections colonized in the nose and increase the risk of infections. Methods: Overall, 85 S. aureus isolates were isolated from clinical and nasal hospitalized patients and health care workers (HCWs) in a burn unit and non-burn units in Isfahan from June 2016 and September 2016. Genes encoding penicillin-binding protein 2a (mecA) and adhesive surface proteins, including fibronectin-binding proteins (fnbA, fnbB), fibrinogen binding protein (fib), laminin-binding protein(eno), collagen binding protein (cna), elastin binding protein (ebps), intracellular adhesion operon (icaA and icaD) were detected using PCR method. Results: The rate of methicillin-resistant S. aureus (MRSA) among burn and non-burn isolates were 62% (18/29) and 25% (14/56), respectively. The most prevalent MSCRAMMs genes in burn units were eno (86%) and fib (66%). The most common gene pattern in burn center was icaA+fib+eno. The frequency of icaD, fib and ebpS was higher in clinical samples than nasal samples. No relation was found between the MSCRAMMs genes in the burn unit and non-burn units. Conclusion: The high prevalence of MRSA in burn center can be a new challenge for clinicians. The higher frequency of icaD, fib and ebpS in clinical isolates than nasal isolates may reflect the important role of these genes in colonization and pathogenesis of S. aureus. https://ijph.tums.ac.ir/index.php/ijph/article/view/15439 https://ijph.tums.ac.ir/index.php/ijph/article/download/15439/7105