Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 47 9 2018 08 29 1244 1252 Hongsheng REN Dept. of Intensive Care Unit, The Provincial Hospital Affiliated to Shandong University, Jinan, China Bo SONG Dept. of Intensive Care Unit, Taishan Medical University Affiliated Zouping Hospital, Zouping, China Pengcheng LI Dept. of Intensive Care Unit, The Provincial Hospital Affiliated to Shandong University, Jinan, China Cheng HUAN Dept. of Intensive Care Unit, The Provincial Hospital Affiliated to Shandong University, Jinan, China Yufeng CHU Dept. of Intensive Care Unit, The Provincial Hospital Affiliated to Shandong University, Jinan, China Min DING Dept. of Intensive Care Unit, The Provincial Hospital Affiliated to Shandong University, Jinan, China Yuping WANG Dept. of Intensive Care Unit, The Provincial Hospital Affiliated to Shandong University, Jinan, China Qingchun YAO Dept. of Intensive Care Unit, The Provincial Hospital Affiliated to Shandong University, Jinan, China Peng WANG Dept. of Intensive Care Unit, The Provincial Hospital Affiliated to Shandong University, Jinan, China Guoqiang QI Dept. of Intensive Care Unit, The Provincial Hospital Affiliated to Shandong University, Jinan, China Chunting WANG Dept. of Intensive Care Unit, The Provincial Hospital Affiliated to Shandong University, Jinan, China 2018 08 29 2018 08 29 Background: We explored the effects of high-volume hemofiltration(HVHF) by different ultrasound directing on the plasma N-terminal pro-B-type natriuretic peptide(NT-Pro-BNP), extra vascular lung water index (EVLWI), liquid net balance quantity and prognosis in patients with septic shock. Methods: Overall, 107 intensive patients with septic shock were enrolled by retrospective analysis from Department of Intensive Care Unit (ICU) of the Shandong Provincial Hospital affiliated to Shandong University from 2014-2017. According to HVHF by different ultrasound directing, all the patients were divided into two groups ((ultrasonic cardiac output monitor (USCOM), group A, n=51cases)) and ((critical bedside ultrasound (CBU), group B, n=56cases)). Results: The value of CI in group A had a significant positive correlation with the value of PCCI by the PiCCO2 monitoring (P＜0.05). The lung ultrasound water B lines in group B also had a significant positive correlation with the value of EVLWI by the PiCCO2 monitoring. The cumulative liquid net balance quantity in group B had a more significant elevation than group A after treatment 7th d. The level of EVLWI after treatment 48 h and 72 h, the level of plasma NT-Pro-BNP, the levels of P(A-a)DO2,OI and blood lactic after treatment 72 h, and the APACHEⅡ scores and SOFA scores after treatment 7thd were reduced more significantly in group B than group A (P<0.001). The mortality at 28th day had a more significant decrease in group B than group A. Conclusion: It could decrease the level of NT-Pro-BNP, EVLWI, P(A-a)DO2,which then improves pulmonary oxygenation. Consequently, it decreased the APACHEⅡand SOFA scores and improved the 28th survival rate of patients.   https://ijph.tums.ac.ir/index.php/ijph/article/view/14575 https://ijph.tums.ac.ir/index.php/ijph/article/download/14575/6105