Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 47 3 2018 03 04 382 389 Marziyeh VAHID DASTJERDI Dept. of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran Bita ESLAMI Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran Maryam ALSADAT SHARIFI Dept. of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran Ashraf MOINI Dept. of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran Leila BAYANI Dept. of Radiology, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran Hoda MOHAMMAD KHANI Dept. of Obstetrics and Gynecology, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran Sadaf ALIPOUR Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran AND Dept. of Surgery, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran 2018 03 04 2018 03 04 Background: Phytoestrogens treatment to relieve hot flushes in menopausal women was considered recently. However, the actual effectiveness and safety are not clear. Methods: Randomized clinical trial (IRCT#20100706004329N5) was performed in 204 patients who complained of hot flushes in Arash Women's Hospital, Tehran, Iran from 2013-2015. The first group received 50 mg isoflavone (group A) once daily and the second group received placebo (group B) in the same regimen. Patients were evaluated for breast examination (BE) and breast sonography (BS) as well as vaginal sonography at initial presentation and at 6th and 12th week follow-ups. Patients were educated to record frequency and severity of hot flushes. Results: Group A experienced less hot flushes attack (6 vs 9 patients with 5< attacks in 6 wk (P= 0.05), 7 Vs 13 patients with 5< in 12 wk (P=0.01)) which was also less severe (8 vs 12 patients with severe symptoms in 6 wk (0.04) and 3 Vs 10 patients with severe symptoms in 12 wk (0.001). Isoflavone had no effect on neither breast density nor nodularity (in 6 wk, P=0.50 and 0.80, respectively and in 12 wk, P=0.32 and 0.43) and neither breast tenderness nor nipple discharge (in 6 wk, P=0.40 and 0.34 respectively and in 12 wk, P= 0.31 and 0.26). There were no significant differences in endometrial thickness in 6 and 12wk. Conclusion: Effects of isoflavone on frequency and severity of hot flushes in perimenopausal women is observed. Some clinical and ultrasonographic benign non-significant changes of the breast and endometrium are noted after isoflavone intake.   https://ijph.tums.ac.ir/index.php/ijph/article/view/12686 https://ijph.tums.ac.ir/index.php/ijph/article/download/12686/5924