Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 47 2 2018 02 03 148 155 Ali KABIR Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran AND Dept. of Epidemiology, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Rezvan ZENDEHDEL Dept. of Occupational Health Engineering, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Raana TAYEFEH-RAHIMIAN Dept. of Occupational Health Engineering, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2018 02 03 2018 02 03 Background: In pesticide exposure groups such as farmers, the risk of prostate cancer was increased, although the report of the cause of evidence is limited. We selected chlorophenol compounds as an important group of the contaminated pesticide with highly toxic 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). This meta-analysis, the risk of death from prostate cancer was analyzed. Methods: PubMed, Scopus, Scholar Google and web of Sciences until 2016 were searched. The standardized mortality rate (SMR) and 95% confidence intervals (CI) were obtained from the studies. We tested statistical heterogeneity with Cochrane Q test and I2 index. Egger test was used for evaluating publication bias. Random or fixed-effects models and meta-regression were also used in our analysis. Moreover, Cochrane tool was used to assess the risk of bias. Results: Five available papers consist of 28706 exposed populations were assessed. Overall standardized mortality rate as combined result of prostate cancer risk from the fixed model was 1.2 (95% confidence interval (CI) 1.02 to 1.42, P=0.027). Some biases are more probable in these studies such as confounding by indication, loss to follow up and misclassification. Conclusion: A contaminated pesticide with dioxins between other pesticides is an important risk factor for prostate cancers.     https://ijph.tums.ac.ir/index.php/ijph/article/view/12398 https://ijph.tums.ac.ir/index.php/ijph/article/download/12398/5888