Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 5 2020 05 01 896 905 EN Hyunseok JEE Frontier Research Institute of Convergence Sports Science (FRICSS), Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea AND School of Kinesiology, Yeungnam University, 280 Daehak-ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea Sae Yong LEE Frontier Research Institute of Convergence Sports Science (FRICSS), Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea AND Integrated Sports Science Research Laboratory (ISSRL), Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea AND Department of Physical Education, College of Sciences in Education, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea 2018 01 09 2018 09 11 Background: Knee disease is prevalent in the post middle-aged and associated with lower quality of life. Knee disease (i.e., anterior cruciate ligament, ACL) related injury preventive program should be supported. We examined the significant effect of different age, gender, and exercise modalities on measureable nine dependent markers in National Health Insurance Sharing Service database (NHISS DB) registered ACL patients using big data analysis. Methods: The 1755 ACL patients from 514,866 in NHISS DB have been randomly selected by retrospective cohort study using big data from 2002 to 2013. Six independent and 9 dependent variables were used for analyzing patients with ACL injuries by T-test and Two-way analysis of variance (ANOVA). Results: Mean (SD) (men vs. women) of BMI, high blood pressure (BP), serum glutamic oxaloacetic transaminase (SGOT), and total cholesterol were 24.38±2.72 vs. 24.86±3.12 (P<0.01, 95% C.I., -0.763 ~ -0.194), 126.64±14.70 vs. 125.02±16.62 (P<0.05, 95% C.I., 0.104 ~ 3.151), 27.63±12.18 vs. 24.27±8.48 (P<0.01, 95% C.I., 2.393 ~ 4.331), 197.77±37.60 vs. 205.72±36.72 (P<0.01, 95% C.I., -11.533 ~ -4.378), respectively. Age and the frequency of 20 min severe exercise per week (Move20_Freq) intensive exercise had a significant association with BMI (P<0.05). Gender and Move20_Freq had a significant association with BP (P<0.05). Conclusion: Age-dependent Move20_Freq is associated with BMI in ACL patients. Women with ACL have higher BMI and cholesterol levels than men. These gender-specific differences can be relieved by exercise. https://ijph.tums.ac.ir/index.php/ijph/article/view/12150 https://ijph.tums.ac.ir/index.php/ijph/article/download/12150/6911