Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 11 2017 11 01 1475 1485 Aman IMRAN Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan Hafiza Yasara QAMAR Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan Qurban ALI Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan AND Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan Hafsa NAEEM Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan Mariam RIAZ Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan Saima AMIN Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan Naila KANWAL Dept. of Plant Breeding and Genetics, University of Agriculture, Faisalabad, Pakistan Fawad ALI Dept. of Plant Breeding and Genetics, University of Agriculture, Faisalabad, Pakistan Southern Cross Plant Science, Southern Cross University, Lismore, Australia Muhammad Farooq SABAR Centre for Applied Molecular Biology, University of the Punjab, Lahore, Pakistan Idrees Ahmad NASIR Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan 2017 11 01 2017 11 01 Background: Cancer is a genetic disease and mainly arises due to a number of reasons include activation of oncogenes, malfunction of tumor suppressor genes or mutagenesis due to external factors. Methods: This article was written from the data collected from PubMed, Nature, Science Direct, Springer and Elsevier groups of journals. Results: Oncogenes are deregulated form of normal proto-oncogenes required for cell division, differentiation and regulation. The conversion of proto-oncogene to oncogene is caused due to translocation, rearrangement of chromosomes or mutation in gene due to addition, deletion, duplication or viral infection. These oncogenes are targeted by drugs or RNAi system to prevent proliferation of cancerous cells. There have been developed different techniques of molecular biology used to diagnose and treat cancer, including retroviral therapy, silencing of oncogenes and mutations in tumor suppressor genes. Conclusion: Among all the techniques used, RNAi, zinc finger nucleases and CRISPR hold a brighter future towards creating a Cancer Free World.     https://ijph.tums.ac.ir/index.php/ijph/article/view/11475 https://ijph.tums.ac.ir/index.php/ijph/article/download/11475/5814