Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 10 2017 10 08 1338 1346 Ae Ri JANG Dept. of Nursing, Songwon University, Gwangju, Korea Keum Seong JANG College of Nursing, Chonnam National University, Gwangju, Korea 2017 10 07 2017 10 07 Background: Ankylosing Spondylitis (AS) is a chronic, progressive, and inflammatory disease. The objective of this study was to construct a hypothetical model to determine factors affecting health-related quality of life (HRQOL) of AS patients (ASHRQOL). Methods: A survey was conducted on 275 patients who visited Chonnam National University Bitgoeul Hospital. Data of different variables were collected over two months in 2015. Results: A hypothetical model did not reach recommended level of fit verification. Therefore, health perception variable was eliminated on theoretical basis. Path between function and HRQOL was added after eliminating unimportant path before completing the final modified model. Conclusion: The final revised model met recommended levels of fit test except AGFI. The model explained 57.6% of ASQOL. Further study is needed to develop efficient interventional strategy for improving ASHRQOL.   https://ijph.tums.ac.ir/index.php/ijph/article/view/11243 https://ijph.tums.ac.ir/index.php/ijph/article/download/11243/5755