Expressions of IFN-γ and IL-4 before and after Treatment of Lupus Nephritis with Traditional Chinese Medicine Combined with Cyclophosphamide and Their Values for Efficacy Prediction and Evaluation

  • Yan JIANG Department of Traditional Chinese Medicine, The First Hospital of Qiqihar City, Qiqihar City 161000, China
  • Qichang ZHANG Department of Traditional Chinese Medicine, The First Hospital of Qiqihar City, Qiqihar City 161000, China
  • Haoyu WANG Department of Basic Science of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin City 150040, China
  • Dabei TANG Department of Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin City 150040, China
  • Yan ZHANG Department of Nephrology, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar City 161006, China
  • Yimo ZHANG Department of Nephrology, Qiqihar Traditional Chinese Medicine Hospital, Qiqihar City 161006, China
  • Li YU Department of Traditional Chinese Medicine, The First Hospital of Qiqihar City, Qiqihar City 161000, China
Keywords:
Interleukin-4;, Traditional Chinese medicine;, Cyclophosphamide;, Lupus nephritis

Abstract

Background: To explore IFN-γ (interferon-γ) and IL-4 (interleukin-4) expressions before and after the treatment of LN (lupus nephritis) and their values for efficacy prediction and evaluation.

Methods: Altogether 107 patients with LN treated in the First Hospital of Qiqihaer City, Qiqihar, China from March 2017 to September 2018 were enrolled. Sixty-two patients were treated with cyclophosphamide and prednisolone (control group), while another 45 patients were treated with Qing Shen Fang based on the control group (observation group). Their clinical efficacy and changes in immune indices after treatment were observed.

Results: Compared with those in the control group, clinical efficacy, IFN-γ, IL-4, hemoglobin, complements C3 and C4, ESR (erythrocyte sedimentation rate), serum IgG, SLEDAI (Systemic Lupus Erythematosus Disease Activity Index) score, and TCMSSS (Traditional Chinese Medicine Syndrome Score Scale) score were significantly improved after treatment in the study group. Based on the observation, IFN-γ and IL-4 could be used as potential indicators for evaluating clinical efficacy.

Conclusion: The combination of cyclophosphamide, prednisolone, and Qing Shen Fang improves conditions of patients with LN and significantly reduces their IFN-γ and IL-4 levels in serum. IFN-γ and IL-4 can be used as potential indicators for the efficacy prediction and evaluation of the disease.

 

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Published
2020-05-04
How to Cite
1.
JIANG Y, ZHANG Q, WANG H, TANG D, ZHANG Y, ZHANG Y, YU L. Expressions of IFN-γ and IL-4 before and after Treatment of Lupus Nephritis with Traditional Chinese Medicine Combined with Cyclophosphamide and Their Values for Efficacy Prediction and Evaluation. Iran J Public Health. 49(5):886-895.
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Original Article(s)