Iranian Journal of Public Health 2017. 46(5):699-704.

Prevalence and Incidence of Multiple Sclerosis in Tehran, Iran
Sharareh ESKANDARIEH, Pouria HEYDARPOUR, Seyedeh-Robab ELHAMI, Mohammad Ali SAHRAIAN

Abstract


Background: Tehran is the capital of Iran with an increasing Multiple Sclerosis (MS) incidence. A retrospective population-based study was conducted to evaluate the status of MS prevalence and MS incidence trends in Tehran Province, Iran.

Methods: A population-based study was conducted from 1991 to 2014 in Tehran Province, the capital city of Iran based on Iranian MS Society (IMSS) registry system. A structured questionnaire design to cover the important epidemiological variables, related at the individual level for MS. A Monte Carlo Permutation method was utilized to test whether the apparent change in MS trends during 1991-2014 was statistically significant.

Results: MS incidence was significantly increased during our study period. The annual percent change (APC) was 12.8% in women during 1991 to 2004 and 12.5% in men during the same period. The point prevalence of MS was 101.39 per 100000 populations in 2014. The age-adjusted prevalence rates were 134.03 and for male patients were 42.45 per 100000.

Conclusion: MS prevalence and incidence in Tehran are markedly rising, it is crucial to elucidate the causes of the increasing trends and implement efficient policies lowering disease burden.

 


Keywords


Multiple sclerosis; Prevalence; Incidence; Joinpoint regression

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References


Koch-Henriksen N, Sørensen P (2010). The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurol, 9:520-32.

Melcon M, Correale J, Melcon C (2014). Is it time for a new global classification of multiple sclerosis? J Neurol Sci, 344(1-2):171-81.

Dua T, Romani P (2008). Atlas of Multiple Sclerosis Resources in the World, WHO, Geneva.

Heydarpour P, Khoshkish S, Abtahi S, Moradi-Lakeh M, Sahraian MA (2015). Multiple Sclerosis Epidemiology in Middle East and North Africa: A Systematic Review and Meta-Analysis. Neuroepidemiology, 44(4):232-244.

Etemadifar M, Izadi S, Nikseresht A, Sharifian M, Sahraian M, Nasr Z (2014). Estimated Prevalence and Incidence of Multiple Sclerosis in Iran. Eur Neurol 72:370-74.

Compston A, Coles A (2002). Multiple sclerosis. Lancet, 359:1221-31.

Sawcer S (2008). The complex genetics of multiple sclerosis: pitfalls and prospects. Brain, 131:3118-31.

Elhami SR, Mohammad K, Sahraian MA, Eftekhar H (2011). A 20-year incidence trend (1989-2008) and point prevalence (March 20, 2009) of multiple sclerosis in Tehran, Iran: a population-based study. Neuroepidemiology, 36:141-7.

Sahraian MA, Khorramnia S, Ebrahim MM, Moinfar Z, Lotfi J, Pakdaman H (2010). Multiple sclerosis in Iran: a demographic study of 8,000 patients and changes over time. Eur Neurol, 64:331-6.

Heydarpour P, Mohammad K, Yekaninejad MS, Elhami SR, Khoshkish S, Sahraian MA (2014). Multiple sclerosis in Tehran, Iran: a joinpoint trend analysis. Mult Scler, 20:512.

McDonald WI, Compston A, Edan G et al (2001). Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol, 50:121-7.

Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW (1983). New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol, 13:227-31.

Jemal A, Ward E, Thun MJ (2007). Recent trends in breast cancer incidence rates by age and tumor characteristics among U.S. women. Breast Cancer Res, 9(3):R28.

O'Flaherty M, Ford E, Allender S, Scarborough P, Capewell S (2008). Coronary heart disease trends in England and Wales from 1984 to 2004: concealed levelling of mortality rates among young adults. Heart, 94:178-81.

Leslie WD, O'Donnell S, Jean S, Lagace C, Walsh P, Bancej C, Morin S, Hanley DA, Papaioannou A, Osteoporosis Surveillance Expert Working G (2009). Trends in hip fracture rates in Canada. JAMA, 302:883-9.

Govindan R, Page N, Morgensztern D, Read W, Tierney R, Vlahiotis A, Spitznagel EL, Piccirillo J (2006). Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol, 24:4539-44.

Al-Hashel J, Besterman AD, Wolfson C (2008). The prevalence of multiple sclerosis in the Middle East. Neuroepidemiology, 31:129-37.

Etemadifar M, Maghzi AH (2011). Sharp increase in the incidence and prevalence of multiple sclerosis in Isfahan, Iran. Mult Scler, 17:1022-7.

Ghandehari K, Riasi HR, Nourian A, Boroumand AR (2010). Prevalence of multiple sclerosis in north east of Iran. Mult Scler, 16:1525-6.

Moghtaderi A, Rakhshanizadeh F, Shahraki-Ibrahimi S (2013). Incidence and prevalence of multiple sclerosis in southeastern Iran. Clin Neurol Neurosurg, 115:304-8.

Wallin MT, Page WF, Kurtzke JF (2004). Multiple sclerosis in US veterans of the Vietnam era and later military service: race, sex, and geography. Ann Neurol, 55:65-71.

Barnett MH, Williams DB, Day S, Macaskill P, McLeod JG (2003). Progressive increase in incidence and prevalence of multiple sclerosis in Newcastle, Australia: a 35-year study. J Neurol Sci, 213:1-6.

Chitnis T, Glanz B, Jaffin S, Healy B (2009). Demographics of pediatric-onset multiple sclerosis in an MS center population from the Northeastern United States. Mult Scler, 15:627-31.

Al Jumah M, Kojan S, Al Khathaami A, Al Abdulkaream I, Al Blawi M, Jawhary A (2011). Familial multiple sclerosis: does consanguinity have a role? Mult Scler, 17:487-9.

Etemadifar M, Janghorbani M, Shaygannejad V, Ashtari F (2006). Prevalence of multiple sclerosis in Isfahan, Iran. Neuroepidemiology, 27:39-44.

Hashemilar M SOD, Farhoudi M,Ayromlou H, Asadollahi A (2011). Multiple sclerosis in east Azerbaijan, north west Iran. Neurology Asia, 16:127-131.

Kalanie H, Gharagozli K, Kalanie AR (2003). Multiple sclerosis: report on 200 cases from Iran. Mult Scler, 9:36-8.

Rezaali S, Khalilnezhad A, Naser Moghadasi A, Chaibakhsh S, Sahraian MA (2013). Epidemiology of multiple sclerosis in Qom: Demographic study in Iran. Iran J Neurol, 12:136-43.

Al-Afasy HH, Al-Obaidan MA, Al-Ansari YA, Al-Yatama SA, Al-Rukaibi MS, Makki NI, Suresh A, Akhtar S (2013). Risk factors for multiple sclerosis in Kuwait: a population-based case-control study. Neuroepidemiology, 40:30-5.

Deleu D, Mir D, Al Tabouki A et al (2013). Prevalence, demographics and clinical characteristics of multiple sclerosis in Qatar. Mult Scler, 19:816-9.


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