Iranian Journal of Public Health 2015. 44(7):892-901.

892 Available at: Genetic of Alzheimer's Disease: A Narrative Review Article


Background: Alzheimer's disease (AD) is one of the most common problems for old peoples. Etiology of AD is not
clear, but genetic factors play a major role in determining a person's risk to develop AD. Twin and family studies con-firm that AD has a genetic basis.AD genetics has been split into two broad categories: early-onset and late-onset. EO-AD cases are inherited in an autosomal dominant pattern. In this form, dominant mutations in genes like APP, PSEN-1 and PSEN-2 associated with AD. This study aimed to consider the role of genetic in AD.
Method: At the first, most of the references in relation with genetic basis of AD searched from the following web-sites: PubMed, Science direct, Wiley & Sons (1995-2014). Then, the most common genes and their affects described briefly.
Results: Aging is the most obvious risk factor for developing AD. There is a genetic basis for AD, of course this rela-tion is not complete but it is significant.
Conclusion: More than thousand genes studied in relation with Alzheimer's disease. Against the improvements in understanding different aspects of AD, the accurate genetic foundation of AD remain unclear.


Alzheimer's disease (AD), Early-onset type (EOAD), Late-onset type (LOAD), Genetic factors

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