Analysis of Mortality from Carcinomas Primary Localized in Re-gion of Lip, Oral Cavity and Pharynx in Central Serbia, 1999-2015

  • Milos M. STEPOVIC Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
  • Dalibor STAJIC Department of Hygiene and Ecology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
  • Marija SEKULIC Department of Hygiene and Ecology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
  • Zlata RAJKOVIC Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
  • Nela DJONOVIC 1. Department of Hygiene and Ecology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia 2. Institute of Public Health, Kragujevac, Serbia
Keywords: Lip neoplasm;, Pharyngeal neoplasm;, Mouth neoplasm;, Serbia

Abstract

Background: Lip, oral cavity, and pharyngeal cancers have been globally estimated to account for about 3.8% of all cancer cases and 3.6% of cancer deaths. Mortality of these cancers is generally higher in developing than in developed countries. Overall cancer mortality rate in Serbia is one of the highest in the world. The aim of this study was to determine the mortality rate trends and the most common localization of lip, oral and pharyngeal cancers in Serbia.

Methods: The study was conducted in 2018 as descriptive epidemiological study and included years from 1999 to 2015. The differences in standardized mortality rates and number of deaths were analyzed with regard to age, gender, and tumor localization. Linear trend and regression were used to determine mortality rate trend.

Results: There was statistically significant difference in the number of deaths between men and women in the ages of 40 and over (P < 0.01); male/female cancer mortality ratio was 4.56:1. Generally, the most common localization of this carcinoma was hypopharynx. There was no statistically significant increase of mortality rates from these cancers for both genders (males: y = 4.77 + 0.42x, P = 0.069 % change = +20.35; females: y = 1.03 + 0.01x, P = 0.40 % change = +4) during 17-year period.

Conclusion: Promotion of healthy habits, life-styles and regular inspection of mouth by patients and health professionals should be better prioritized especially in developing countries where implementing and improving national health prevention programs are essential.

References

1. Shield KD, Ferlay J, Jemal A et al (2017). The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin, 67(1): 51-64.
2. Warnakulasuriya S (2009). Global epidemiol-ogy of oral and oropharyngeal cancer. Oral Oncol, 45(4-5): 309-16.
3. Khan Z, Tönnies J, Müller S (2014). Smoke-less Tobacco and Oral Cancer in South Asia: A Systematic Review with Meta-Analysis. J Cancer Epidemiol, 2014: 1-11.
4. Scully C, Bagan J (2009). Oral squamous cell carcinoma overview. Oral Oncol, 45: 301-8.
5. Shah JP (2001). Cancer of the Head and Neck. Atlas of clinical oncology. Hamilton-London: BC Decker Inc, 1-146.
6. Shah JP, Gil Z (2009). Current concepts in management of oral cancer surgery. Oral Oncol, 45(4-5): 394-401.
7. Langendijk JA, Ferlito A, Takes RP et al (2010). Postoperative strategies after pri-mary surgery for squamous cell carcino-ma of the head and neck. Oral Oncol, 46: 577-85.
8. Siddiqi K, Scammell K, Huque R et al (2015). Smokeless Tobacco Supply Chain in South Asia: A Comparative Analysis Us-ing the WHO Framework Convention on Tobacco Control. Nicotine Tob Res, 18(4): 424-430.
9. Gupta N, Gupta R, Acharya AK et al (2016). Changing Trends in oral cancer - a global scenario. Nepal J Epidemiol, 6(4): 613-619.
10. Bunget AM, Dascălu IT, Coleș E et al (2018). Histopathological Aspects in Oral Squamous Cell Carcinoma. J Dental Sci, 3(3): 000173.
11. Ghantous Y, Abu Elnaaj I (2017). Global Incidence and Risk Factors of Oral Can-cer. Harefuah, 156(10): 645-649.
12. Kumar M, Nanavati R, Modi TG, Dobariya C (2016). Oral cancer: Etiology and risk factors: A review. J Cancer Res Ther, 12(2): 458-63.
13. Diz P, Meleti M, Diniz-Freitas M et al (2017). Oral and pharyngeal cancer in Europe: Incidence, mortality and trends as pre-sented to the Global Oral Cancer Fo-rum. Transl Res Oral Oncol, 2: 1-13.
14. World Health Organization (2018). Interna-tional Agency for Research on Cancer. Cancer Today. Available from: http://gco.iarc.fr/today/home
15. Jensen OM, Parkin DM, MacLennan R, Muir CS, Skeet RG (1991). Cancer registra-tion. Principles and Methods. Lyon: IARC.
16. Ilic М, Radevic S, Stefanovic V et al (2013). Mortality rate of lip, oral cavity and phar-ynx malignant tumors in Serbia within a period 1991–2009. Vojnosanit Pregl, 70(2): 189-194.
17. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J et al (2013). Cancer incidence and mortality patterns in Europe: esti-mates for 40 countries in 2012. Eur J Can-cer, 49(6): 1374-403.
18. Markovic-Denic L, Cirkovic A, Zivkovic S, Stanic D, Skodic TV (2014). Cancer mor-tality in central Serbia. J BUON, 19(1): 273-7.
19. Mihajlovic J, Pechlivanoglou P, Miladinov-Mikov M, Zivkovic S, Postma MJ (2013). Cancer incidence and mortality in Serbia 1999–2009. BMC Cancer, 13:18.
20. Ferlay J, Colombet M, Soerjomataram I et al (2018). Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. Eur J Cancer, 103:356-387.
21. Petersen JF, Timmermans AJ, van Dijk B et al (2018). Trends in treatment, incidence and survival of hypopharynx cancer: a 20-year population-based study in the Netherlands. Eur Arch Otorhinolaryngo, 275(1): 181-189.
22. Gatta G, Botta L, Sanchez MJ, Anderson LA, Pierannunzio D, Licitra L (2015). Prognoses and improvement for head and neck cancers diagnosed in Europe in early 2000s: the EUROCARE-5 popula-tion-based study. Eur J Cancer, 51(15): 2130-43.
23. Yako-Suketomo H, Matsuda T (2010). Comparison of time trends in lip, oral cavity and pharynx cancer mortality (1990-2006) between countries based on the WHO mortality database. Jpn J Clin Oncol, 40(11):1118-9.
24. Janbaz KH, Qadir MI, Basser HT et al (2014). Review Risk for oral cancer from smokeless tobacco. Contemp Oncol (Pozn), 18(3): 160-164.
25. The Institute of Public Health of Serbia “Dr Milan JovanovićBatut” (2014). Results of The National Health Survey Of The Re-public Of Serbia 2013. Belgrade. Available from: http://www.batut.org.rs/download/publikacije/2013SerbiaHealthSurvey.pdf
26. Goldstein BY, Chang S-C, Hashibe M et al (2010). Alcohol consumption and cancers of the oral cavity and pharynx from 1988 to 2009: an update. Eur J Cancer Prev, 19(6): 431-465.
27. Khanna R, Kumar A, Khanna R (2018). Di-et-Nutrition and Cancer Prevention (Re-view). IJDMS, 1(2):33-37.
28. Rettig EM, Wentz A, Posner MR et al (2015). Prognostic Implication of Persis-tent Human Papillomavirus Type 16 DNA Detection in Oral Rinses for Hu-man Papillomavirus–Related Oropharyn-geal Carcinoma. JAMA Oncol, 1(7): 907-15.
29. Jain M (2016). Assessment of Correlation of Herpes Simplex Virus-1 with Oral Cancer and Precancer- A Comparative Study. J Clin Diagn Res, 10(8): ZC14-ZC17.
30. Piemonte E, Lazos J, Belardinelli P et al (2018). Oral cancer associated with chronic mechanical irritation of the oral mucosa. Med Oral Patol Oral Cir Bucal, 23(2): e151-e160.
31. Kharadi U, Kharadi UA, Parkarwar P et al (2016). Oral Candidiasis Turns to Oral Cancer – A Rare Clinical Presentation. Clin Oncol, 1: 1126.
Published
2020-02-01
How to Cite
1.
STEPOVIC MM, STAJIC D, SEKULIC M, RAJKOVIC Z, DJONOVIC N. Analysis of Mortality from Carcinomas Primary Localized in Re-gion of Lip, Oral Cavity and Pharynx in Central Serbia, 1999-2015. Iran J Public Health. 49(2):274-282.
Section
Original Article(s)